| Literature DB >> 3345724 |
J Isgaard1, C Möller, O G Isaksson, A Nilsson, L S Mathews, G Norstedt.
Abstract
The mechanism of action for the stimulatory effect of GH on longitudinal bone growth is not yet clarified. Several recent reports indicate that GH has a direct effect at the site of the epiphyseal growth plate, as opposed to the somatomedin hypothesis which holds that the effect of GH is mediated by circulating insulin-like growth factors (IGFs). Using a RNA probe in a solution hybridization assay we investigated the presence of IGF-I mRNA in rat rib growth plate. Hypophysectomy resulted in a decrease in the number of IGF-I mRNA copies compared to that in normal rats. Replacement treatment with GH restored the number of transcripts in a specific and dose-dependent manner. The results show that GH regulates the level of IGF-I mRNA in rat rib growth plate and give further support to the hypothesis that locally produced IGF-I might contribute to the stimulatory effect of GH on longitudinal bone growth.Entities:
Mesh：
Substances：
Year: 1988 PMID： 3345724 DOI： 10.1210/endo-122-4-1515
Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736