Ao Ren1,2,3, Zhongqiu Li1,2,3, Xuzhi Zhang1,2,3, Ronghai Deng1,2,3, Yi Ma1,2,3. 1. Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 2. Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 3. Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Abstract
BACKGROUND: It is important to select appropriate patients for improving the outcomes of liver transplantation for intrahepatic cholangiocarcinoma (iCCA). The objective of this study was to establish a predictive model for the recurrence of iCCA after liver transplantation. METHODS: Twenty-one patients who received liver transplantation for iCCA were used to construct a model for predicting recurrence. Predictors of recurrence were tested by a Cox model analysis. The results were validated in 28 patients who were followed up. RESULTS: Diameter and number of tumors, and CA19-9 level independently predicted tumor recurrence. At a Cox score threshold of 0.736 [95% confidence interval (CI): 0.549-0.923], a model combining these factors was highly predictive of tumor recurrence and death. A simplified version of the model identified a cut-off value of 6. The 5-year OS rate was lower in patients with a score >6 points compared to those with a score ≤6 points (P=0.005). The 5-year recurrence rate was higher in patients with a score >6 points as compared to those with a score ≤6 points (P=0.034). CONCLUSIONS: The model developed was useful for predicting recurrence of iCCA after liver transplantation. Large sample, multicenter studies are needed to validate the findings. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
BACKGROUND: It is important to select appropriate patients for improving the outcomes of liver transplantation for intrahepatic cholangiocarcinoma (iCCA). The objective of this study was to establish a predictive model for the recurrence of iCCA after liver transplantation. METHODS: Twenty-one patients who received liver transplantation for iCCA were used to construct a model for predicting recurrence. Predictors of recurrence were tested by a Cox model analysis. The results were validated in 28 patients who were followed up. RESULTS: Diameter and number of tumors, and CA19-9 level independently predicted tumor recurrence. At a Cox score threshold of 0.736 [95% confidence interval (CI): 0.549-0.923], a model combining these factors was highly predictive of tumor recurrence and death. A simplified version of the model identified a cut-off value of 6. The 5-year OS rate was lower in patients with a score >6 points compared to those with a score ≤6 points (P=0.005). The 5-year recurrence rate was higher in patients with a score >6 points as compared to those with a score ≤6 points (P=0.034). CONCLUSIONS: The model developed was useful for predicting recurrence of iCCA after liver transplantation. Large sample, multicenter studies are needed to validate the findings. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
Entities:
Keywords:
Intrahepatic cholangiocarcinoma; liver transplantation; model
Authors: John Bridgewater; Peter R Galle; Shahid A Khan; Josep M Llovet; Joong-Won Park; Tushar Patel; Timothy M Pawlik; Gregory J Gores Journal: J Hepatol Date: 2014-03-27 Impact factor: 25.083
Authors: G Sapisochin; M Facciuto; L Rubbia-Brandt; J Marti; N Mehta; F Y Yao; E Vibert; D Cherqui; D R Grant; R Hernandez-Alejandro; C H Dale; A Cucchetti; A Pinna; S Hwang; S G Lee; V G Agopian; R W Busuttil; S Rizvi; J K Heimbach; M Montenovo; J Reyes; M Cesaretti; O Soubrane; T Reichman; J Seal; P T W Kim; G Klintmalm; C Sposito; V Mazzaferro; P Dutkowski; P A Clavien; C Toso; P Majno; N Kneteman; C Saunders; J Bruix Journal: Hepatology Date: 2016-08-24 Impact factor: 17.425