Yue'e Dai1,2, Rong Jiang2, Wenjie Su2, Man Wang2, Yue Liu2, Yunxia Zuo1. 1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China. 2. Department of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Abstract
BACKGROUND: To explore the effect of perioperative intravenous lidocaine infusion on postoperative pain and the rapid recovery of patients undergoing gastrointestinal tumor surgery. METHODS: The patients who underwent gastrointestinal tumor surgery from May to July 2020 were selected. The patients were randomly divided into the lidocaine group (group L) and control group (group C) by the random number table method, with 60 patients in each group. Both groups of patients received an intravenous drug infusion immediately after induction of tracheal intubation under general anesthesia. In group L, 1.5 mg/kg lidocaine was slowly injected intravenously at a rate of 1.5 mg·kg-1·h-1 to the surgical suture, and intravenous inhalation was used to maintain the depth of anesthesia. Group C patients were given the same volume of normal saline. The 2-, 4-, 7-, 14-, 30-, and 90-day numerical rating scale (NRS) and the proportion of chronic post-surgical pain (CPSP) after 3 months for both groups after surgery were recorded. Each patient's postoperative comfort score, requiring analgesia, return of flatus, bowl movement, hospitalization days, hospitalization expenses, and adverse events were also recorded. RESULTS: One hundred and twenty patients were enrolled but 5 of them failed to complete the treatment process. Therefore, 58 and 57 patients in group L and C were included into the final analysis. The NRS of patients in group L was significantly lower than that of group C at all time points after surgery (P<0.05), and the proportion of CPSP in group L was significantly lower than that of group C (P<0.05). The percentage of patients requiring analgesia and postoperative comfort score of group L was significantly higher than that of group C (P<0.01), patient's return of flatus, bowl movement, hospitalization days, and hospitalization expenses in group L were significantly lower than those in group C (P<0.05). There were no difference of adverse events between the 2 groups (P>0.05). CONCLUSIONS: During the perioperative period of radical gastrointestinal tumor surgery, intravenous lidocaine infusion can reduce acute postoperative pain, promote postoperative gastrointestinal function recovery, and improve postoperative comfort. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
BACKGROUND: To explore the effect of perioperative intravenous lidocaine infusion on postoperative pain and the rapid recovery of patients undergoing gastrointestinal tumor surgery. METHODS: The patients who underwent gastrointestinal tumor surgery from May to July 2020 were selected. The patients were randomly divided into the lidocaine group (group L) and control group (group C) by the random number table method, with 60 patients in each group. Both groups of patients received an intravenous drug infusion immediately after induction of tracheal intubation under general anesthesia. In group L, 1.5 mg/kg lidocaine was slowly injected intravenously at a rate of 1.5 mg·kg-1·h-1 to the surgical suture, and intravenous inhalation was used to maintain the depth of anesthesia. Group C patients were given the same volume of normal saline. The 2-, 4-, 7-, 14-, 30-, and 90-day numerical rating scale (NRS) and the proportion of chronic post-surgical pain (CPSP) after 3 months for both groups after surgery were recorded. Each patient's postoperative comfort score, requiring analgesia, return of flatus, bowl movement, hospitalization days, hospitalization expenses, and adverse events were also recorded. RESULTS: One hundred and twenty patients were enrolled but 5 of them failed to complete the treatment process. Therefore, 58 and 57 patients in group L and C were included into the final analysis. The NRS of patients in group L was significantly lower than that of group C at all time points after surgery (P<0.05), and the proportion of CPSP in group L was significantly lower than that of group C (P<0.05). The percentage of patients requiring analgesia and postoperative comfort score of group L was significantly higher than that of group C (P<0.01), patient's return of flatus, bowl movement, hospitalization days, and hospitalization expenses in group L were significantly lower than those in group C (P<0.05). There were no difference of adverse events between the 2 groups (P>0.05). CONCLUSIONS: During the perioperative period of radical gastrointestinal tumor surgery, intravenous lidocaine infusion can reduce acute postoperative pain, promote postoperative gastrointestinal function recovery, and improve postoperative comfort. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
Authors: Annemieke Cats; Edwin P M Jansen; Nicole C T van Grieken; Karolina Sikorska; Pehr Lind; Marianne Nordsmark; Elma Meershoek-Klein Kranenbarg; Henk Boot; Anouk K Trip; H A Maurits Swellengrebel; Hanneke W M van Laarhoven; Hein Putter; Johanna W van Sandick; Mark I van Berge Henegouwen; Henk H Hartgrink; Harm van Tinteren; Cornelis J H van de Velde; Marcel Verheij Journal: Lancet Oncol Date: 2018-04-09 Impact factor: 41.316
Authors: Peter Kranke; Johanna Jokinen; Nathan Leon Pace; Alexander Schnabel; Markus W Hollmann; Klaus Hahnenkamp; Leopold H J Eberhart; Daniel M Poepping; Stephanie Weibel Journal: Cochrane Database Syst Rev Date: 2015-07-16
Authors: S Weibel; J Jokinen; N L Pace; A Schnabel; M W Hollmann; K Hahnenkamp; L H J Eberhart; D M Poepping; A Afshari; P Kranke Journal: Br J Anaesth Date: 2016-06 Impact factor: 9.166
Authors: Hui Liu; Fan Lu; Dan Zhou; Yan Yin; Jun Li; BangXiang Yang; Li Song; Ling Ye; Hong Xiao Journal: Clin J Pain Date: 2018-11 Impact factor: 3.442
Authors: Eben J Clattenburg; Anthony Nguyen; Tina Yoo; Stefan Flores; Christian Hailozian; Derex Louie; Andrew A Herring Journal: Pain Med Date: 2019-04-01 Impact factor: 3.750
Authors: P S Myles; O Boney; M Botti; A M Cyna; T J Gan; M P Jensen; H Kehlet; A Kurz; G S De Oliveira; P Peyton; D I Sessler; M R Tramèr; C L Wu; Paul Myles; Michael Grocott; Bruce Biccard; Jane Blazeby; Oliver Boney; Matthew Chan; Elisabeth Diouf; Lee Fleisher; Cor Kalkman; Andrea Kurz; Ramani Moonesinghe; Duminda Wijeysundera Journal: Br J Anaesth Date: 2018-02-02 Impact factor: 9.166
Authors: Sara J Hyland; Kara K Brockhaus; William R Vincent; Nicole Z Spence; Michelle M Lucki; Michael J Howkins; Robert K Cleary Journal: Healthcare (Basel) Date: 2021-03-16