Literature DB >> 33456595

Transgenerational Effects of Traumatic Historical Events on the Incidence of Metabolic Syndrome/ Nonalcoholic Fatty Liver Disease in the Romanian Population.

Victor Stoica1,2, Daniel Adrian Gardan3, Ileana Constantinescu4,5, Iuliana Petronela Gardan3, Bogdan Calenic6, Mircea Diculescu1,2.   

Abstract

Concerns for successful public health management are integrated into the core business of government-responsible institutions. Diseases associated with metabolic syndrome are very common in the Romanian population. In our study, we focused on the cardiovascular and non-alcoholic fatty liver disease (NAFLD). The article starts from the hypothesis that the increased incidence of such diseases is determined today by the cumulative effect of traumatic historical events such as the famine of 1946-47 and the communist political regime specific to the 80s and 90s. This study aims to present the arguments that indicate the correlation of economic variables whose variation can be easily determined by traumatic events that affected the economy, with variables able to measure the incidence of various diseases usually associated with metabolic syndrome or NAFLD. A series of statistical data were analyzed from the official sources available in the form of consecutive value data for the 1995-2018 period. The results highlighted a direct and strong link between the variable gross domestic product (GDP) per capita in USD, 2011 purchasing power parity (PPP) and specific incidence of circulatory, nutritional endocrine and metabolic diseases, as well as a strong and inverse link between GDP and infant's deaths per 1000 live births. Conclusions highlight that the effects of traumatic historical events must be made aware through medical education of the population, supporting the idea according to which the incidence of various metabolic diseases is greater for the offspring of those who have actively suffered during such events. ©Carol Davila University Press.

Entities:  

Keywords:  Metabolic disease; lifestyle; transgenerational epigenetic inheritance; traumatic event

Year:  2020        PMID: 33456595      PMCID: PMC7803300          DOI: 10.25122/jml-2020-0156

Source DB:  PubMed          Journal:  J Med Life        ISSN: 1844-122X


  43 in total

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Review 2.  A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement.

Authors:  Mohammed Eslam; Philip N Newsome; Shiv K Sarin; Quentin M Anstee; Giovanni Targher; Manuel Romero-Gomez; Shira Zelber-Sagi; Vincent Wai-Sun Wong; Jean-François Dufour; Jörn M Schattenberg; Takumi Kawaguchi; Marco Arrese; Luca Valenti; Gamal Shiha; Claudio Tiribelli; Hannele Yki-Järvinen; Jian-Gao Fan; Henning Grønbæk; Yusuf Yilmaz; Helena Cortez-Pinto; Claudia P Oliveira; Pierre Bedossa; Leon A Adams; Ming-Hua Zheng; Yasser Fouad; Wah-Kheong Chan; Nahum Mendez-Sanchez; Sang Hoon Ahn; Laurent Castera; Elisabetta Bugianesi; Vlad Ratziu; Jacob George
Journal:  J Hepatol       Date:  2020-04-08       Impact factor: 25.083

Review 3.  Effects of exercise on proactive interference in memory: potential neuroplasticity and neurochemical mechanisms.

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Journal:  Psychopharmacology (Berl)       Date:  2020-06-02       Impact factor: 4.530

Review 4.  Environmental and nutritional effects on the epigenetic regulation of genes.

Authors:  Robert Feil
Journal:  Mutat Res       Date:  2006-07-18       Impact factor: 2.433

5.  Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta.

Authors:  Amanda C Filiberto; Matthew A Maccani; Devin Koestler; Charlotte Wilhelm-Benartzi; Michele Avissar-Whiting; Carolyn E Banister; Luc A Gagne; Carmen J Marsit
Journal:  Epigenetics       Date:  2011-05-01       Impact factor: 4.528

6.  Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses.

Authors:  Tim F Oberlander; Joanne Weinberg; Michael Papsdorf; Ruth Grunau; Shaila Misri; Angela M Devlin
Journal:  Epigenetics       Date:  2008 Mar-Apr       Impact factor: 4.528

Review 7.  Epigenetic influences on brain development and plasticity.

Authors:  Michela Fagiolini; Catherine L Jensen; Frances A Champagne
Journal:  Curr Opin Neurobiol       Date:  2009-06-21       Impact factor: 6.627

8.  Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor.

Authors:  K M Radtke; M Ruf; H M Gunter; K Dohrmann; M Schauer; A Meyer; T Elbert
Journal:  Transl Psychiatry       Date:  2011-07-19       Impact factor: 6.222

Review 9.  Early experiences and the development of emotional learning systems in rats.

Authors:  Bridget L Callaghan; Rick Richardson
Journal:  Biol Mood Anxiety Disord       Date:  2013-04-10

Review 10.  Health marketing and behavioral change: a review of the literature.

Authors:  Cristina-Mihaela Chichirez; Victor Lorin Purcărea
Journal:  J Med Life       Date:  2018 Jan-Mar
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