| Literature DB >> 33456571 |
Zeyin Rong1,2,3,4, Jin Xu1,2,3,4, Si Shi1,2,3,4, Zhen Tan1,2,3,4, Qingcai Meng1,2,3,4, Jie Hua1,2,3,4, Jiang Liu1,2,3,4, Bo Zhang1,2,3,4, Wei Wang1,2,3,4, Xianjun Yu1,2,3,4, Chen Liang1,2,3,4.
Abstract
Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs), a class of endogenous ncRNAs with unique covalently closed loops, have attracted great attention in regard to various diseases, especially cancers. Compelling studies have suggested that circRNAs are aberrantly expressed in different cancer tissues and cell types, including PC. More specifically, circRNAs can modify the proliferation, progression, tumorigenesis and chemosensitivity of PC, and some circRNAs could serve as biomarkers for diagnosis and prognosis. Herein, we summarize what is currently known to be related to the biogenesis, functions and potential roles of human circRNAs in PC and their application prospects for PC clinical treatments. © The author(s).Entities:
Keywords: Circular RNA; biomarker; pancreatic cancer; sponge function; treatment
Year: 2021 PMID： 33456571 PMCID： PMC7806488 DOI： 10.7150/thno.56174
Source DB: PubMed Journal: Theranostics ISSN： 1838-7640 Impact factor: 11.556