| Literature DB >> 33456354 |
Hui Li1, Hui-Min Zhang2, Li-Juan Fan3, Han-Han Li2, Zi-Tan Peng4, Jia-Peng Li2, Xiao-Yu Zhang2, Yuan Xiang2, Chao-Jiang Gu2, Xing-Hua Liao2, Li Wang5, Tong-Cun Zhang2,6.
Abstract
Endothelial cell proliferation disorder caused by vascular injury seems to be one of the causes of atherosclerosis, which is the pathological basis of coronary heart disease. The role of STAT3 in the regulation of microRNAs and endothelial dysfunction in atherosclerosis is unclear. STAT3 can be activated by cytokine IL-6 and up regulate the expression of CX3CL1. In addition, microRNA-15a-5p (miR-15a-5p) inhibited the transcription of CX3CL1, the proliferation of vascular endothelial cells and the proliferation of STAT3 regulated vascular endothelial cells. STAT3 positively regulates the expression of CX3CL1, and then down-regulates the inhibition of CX3CL1 by over-expression of miR-15a-5p, thus forming an elimination feedback loop to control the proliferation of HUVECs and affect the progression of atherosclerosis. In conclusion, miR-15a-5p may be the therapeutic target of the pathological basis of coronary atherosclerosis. © The author(s).Entities:
Keywords: Atherosclerosis; CX3CL1; Endothelial cells; MicroRNA-15a; STAT3
Year: 2021 PMID： 33456354 PMCID： PMC7807201 DOI： 10.7150/ijms.49460
Source DB: PubMed Journal: Int J Med Sci ISSN： 1449-1907 Impact factor: 3.738