Fereshteh Ghahvechi Khaligh1,2, Abbas Jafari3,4, Elena Silivanova5, Mikhail Levchenko5, Bahlol Rahimi6, Saber Gholizadeh7,8. 1. Social Determinants of Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran. 2. Medical Entomology Department, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran. 3. Department of Clinical Toxicology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. 4. Cellular and Molecular Research Center, Research Institute on Cellular and Molecular Medicine, Urmia University of Medical Sciences, Urmia, Iran. 5. All-Russian Scientific Research Institute of Veterinary Entomology and Arachnology, Branch of Federal State Institution Federal Research Centre Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences (ASRIVEA - Branch of Tyumen Scientific Centre SB RAS), Institutskaya st. 2, Tyumen, Russian Federation, 625041. 6. Department of Health Information Technology, School of Applied Medical Sciences, Urmia University of Medical Sciences, Urmia, Iran. 7. Social Determinants of Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran. saber@umsu.ac.ir. 8. Medical Entomology Department, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran. saber@umsu.ac.ir.
Abstract
BACKGROUND: Malaria is the most common vector-borne disease transmitted to humans by Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be valuable for trial design and clinical studies to control malaria transmission. METHODS: PubMed/MEDLINE, Scopus, Web of Science, and Science Direct were searched for original English published papers on ("Malaria chemical control" OR "Malaria elimination" OR "Anopheles vector control" OR "Malaria zooprophylaxis") AND ("Systemic insecticides" OR "Endectocides" OR "Ivermectin"). The last search was from 19 June 2019 to 31 December 2019. It was updated on 17 November 2020. Two reviewers (SG and FGK) independently reviewed abstracts and full-text articles. Data were extracted by one person and checked by another. As meta-analyses were not possible, a qualitative summary of results was performed. RESULTS: Thirty-six published papers have used systemic insecticides/endectocides for mosquito control. Most of the studies (56.75%) were done on Anopheles gambiae complex species on doses from 150 μg/kg to 400 μg/kg in several studies. Target hosts for employing systemic insecticides/drugs were animals (44.2%, including rabbit, cattle, pig, and livestock) and humans (32.35%). CONCLUSIONS: Laboratory and field studies have highlighted the potential of endectocides in malaria control. Ivermectin and other endectocides could soon serve as novel malaria transmission control tools by reducing the longevity of Anopheles mosquitoes that feed on treated hosts, potentially decreasing Plasmodium parasite transmission when used as mass drug administration (MDA).
BACKGROUND:Malaria is the most common vector-borne disease transmitted to humans by Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be valuable for trial design and clinical studies to control malaria transmission. METHODS: PubMed/MEDLINE, Scopus, Web of Science, and Science Direct were searched for original English published papers on ("Malaria chemical control" OR "Malaria elimination" OR "Anopheles vector control" OR "Malaria zooprophylaxis") AND ("Systemic insecticides" OR "Endectocides" OR "Ivermectin"). The last search was from 19 June 2019 to 31 December 2019. It was updated on 17 November 2020. Two reviewers (SG and FGK) independently reviewed abstracts and full-text articles. Data were extracted by one person and checked by another. As meta-analyses were not possible, a qualitative summary of results was performed. RESULTS: Thirty-six published papers have used systemic insecticides/endectocides for mosquito control. Most of the studies (56.75%) were done on Anopheles gambiae complex species on doses from 150 μg/kg to 400 μg/kg in several studies. Target hosts for employing systemic insecticides/drugs were animals (44.2%, including rabbit, cattle, pig, and livestock) and humans (32.35%). CONCLUSIONS: Laboratory and field studies have highlighted the potential of endectocides in malaria control. Ivermectin and other endectocides could soon serve as novel malaria transmission control tools by reducing the longevity of Anopheles mosquitoes that feed on treated hosts, potentially decreasing Plasmodium parasite transmission when used as mass drug administration (MDA).
Authors: Tom L McTier; Nathan Chubb; Michael P Curtis; Laura Hedges; Gregory A Inskeep; Christopher S Knauer; Sanjay Menon; Brian Mills; Aleah Pullins; Erich Zinser; Debra J Woods; Patrick Meeus Journal: Vet Parasitol Date: 2016-02-23 Impact factor: 2.738
Authors: S Gholizadeh; S Firooziyan; H Ladonni; H Mohammadzadeh Hajipirloo; N Dinparast Djadid; A Hosseini; A Raz Journal: Acta Trop Date: 2015-03-17 Impact factor: 3.112
Authors: André Lin Ouédraogo; Guido J H Bastiaens; Alfred B Tiono; Wamdaogo M Guelbéogo; Kevin C Kobylinski; Alphonse Ouédraogo; Aïssata Barry; Edith C Bougouma; Issa Nebie; Maurice San Ouattara; Kjerstin H W Lanke; Lawrence Fleckenstein; Robert W Sauerwein; Hannah C Slater; Thomas S Churcher; Sodiomon B Sirima; Chris Drakeley; Teun Bousema Journal: Clin Infect Dis Date: 2014-11-19 Impact factor: 9.079
Authors: Massamba Sylla; Kevin C Kobylinski; Meg Gray; Phillip L Chapman; Moussa D Sarr; Jason L Rasgon; Brian D Foy Journal: Malar J Date: 2010-12-20 Impact factor: 2.979