| Literature DB >> 33454554 |
Gaku Yamanaka1, Tomoko Takamatsu2, Shinichiro Morichi2, Takashi Yamazaki2, Izuru Mizoguchi3, Koko Ohno2, Yusuke Watanabe2, Yu Ishida2, Shingo Oana2, Shinji Suzuki2, Yasuyo Kashiwagi2, Fuyuko Takata4, Hiroshi Sakuma5, Takayuki Yoshimoto3, Mitsuhiro Kato6, Hisashi Kawashima2.
Abstract
In this study, we assessed circulating immune cells and plasma cytokine levels in 15 pediatric patients with drug-resistant epilepsy (DRE). DRE patients had a significantly higher percentage of CD14+ monocytes positive for IL-1β, IL-1 receptor antagonist, IL-6, and TNF-α than controls. Significantly higher intracellular levels of IFN-γ in CD4+ T cells and NK cells were also found in DRE patients. The level of IL-1β+ CD14+ monocytes correlated with seizure frequency, and intracellular levels of IFN-γ in NKT-like cells were negatively correlated with the duration of epilepsy. Peripheral immune cells might be involved in the pathogenesis of DRE.Entities:
Keywords: Cytokine; Drug-resistant epilepsy; Epilepsy; IL-1β; Monocytes
Year: 2021 PMID： 33454554 DOI： 10.1016/j.jneuroim.2021.577475
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478