Caoilfhionn Ní Leidhin1, Jason McMorrow1, Daniel Carey2, Louise Newman2, Wilby Williamson3, Andrew J Fagan4, Michael A Chappell5, Rose Anne Kenny6, James F Meaney1, Silvin P Knight7. 1. School of Medicine, Trinity College Dublin, Ireland; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, Ireland. 2. School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland. 3. School of Medicine, Trinity College Dublin, Ireland; The Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland. 4. Department of Radiology, Mayo Clinic, Rochester, MN, USA. 5. Radiological Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Sir Peter Mansfield Imaging Center, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Nottingham Biomedical Research Centre, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom; Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. 6. School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland; The Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland; Mercer's Institute for Successful Ageing, St. James's Hospital, Dublin, Ireland. 7. School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland. Electronic address: silvin.knight@tcd.ie.
Abstract
OBJECTIVE: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. BACKGROUND: Quantitative assessment of CBFGM may provide an imaging biomarker for the early detection of those at risk of neurodegenerative diseases, such as Alzheimer's and dementia. However, the use of this method to differentiate normal age-related decline in CBFGM from pathological reduction has been hampered by the lack of reference values for cerebral perfusion. METHODS: The study cohort comprised a subset of wave 3 (2014-2015) participants from The Irish Longitudinal Study on Ageing (TILDA), a large-scale prospective cohort study of individuals aged 50 and over. Of 4309 participants attending for health centre assessment, 578 individuals returned for 3T multi-parametric MRI brain examinations. In total, CBFGM data acquired from 468 subjects using pCASL-MRI were included in this analysis. Normative values were estimated using Generalised Additive Models for Location Shape and Scale (GAMLSS) and are presented as percentiles, means and standard deviations. RESULTS: The mean age of the cohort was 68.2 ± 6.9 years and 51.7% were female. Mean CBFGM for the cohort was 36.5 ± 8.2 ml/100 g/min. CBFGM decreased by 0.2 ml/100 g/min for each year increase in age (95% CI = -0.3, -0.1; p ≤ 0.001) and was 3.1 ml/100 g/min higher in females (95% CI = 1.6, 4.5; p ≤ 0.001). CONCLUSIONS: This study is by far the largest single-site study focused on an elderly community-dwelling cohort to present normative reference values for CBFGM measured at 3T using pCASL-MRI. Significant age- and sex-related differences exist in CBFGM.
OBJECTIVE: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. BACKGROUND: Quantitative assessment of CBFGM may provide an imaging biomarker for the early detection of those at risk of neurodegenerative diseases, such as Alzheimer's and dementia. However, the use of this method to differentiate normal age-related decline in CBFGM from pathological reduction has been hampered by the lack of reference values for cerebral perfusion. METHODS: The study cohort comprised a subset of wave 3 (2014-2015) participants from The Irish Longitudinal Study on Ageing (TILDA), a large-scale prospective cohort study of individuals aged 50 and over. Of 4309 participants attending for health centre assessment, 578 individuals returned for 3T multi-parametric MRI brain examinations. In total, CBFGM data acquired from 468 subjects using pCASL-MRI were included in this analysis. Normative values were estimated using Generalised Additive Models for Location Shape and Scale (GAMLSS) and are presented as percentiles, means and standard deviations. RESULTS: The mean age of the cohort was 68.2 ± 6.9 years and 51.7% were female. Mean CBFGM for the cohort was 36.5 ± 8.2 ml/100 g/min. CBFGM decreased by 0.2 ml/100 g/min for each year increase in age (95% CI = -0.3, -0.1; p ≤ 0.001) and was 3.1 ml/100 g/min higher in females (95% CI = 1.6, 4.5; p ≤ 0.001). CONCLUSIONS: This study is by far the largest single-site study focused on an elderly community-dwelling cohort to present normative reference values for CBFGM measured at 3T using pCASL-MRI. Significant age- and sex-related differences exist in CBFGM.
Authors: Laura Pérez-Denia; Paul Claffey; Lisa Byrne; Ciara Rice; Rose Anne Kenny; Ciarán Finucane Journal: J Am Geriatr Soc Date: 2022-05-10 Impact factor: 7.538
Authors: Silvin P Knight; Eamon Laird; Wilby Williamson; John O'Connor; Louise Newman; Daniel Carey; Celine De Looze; Andrew J Fagan; Michael A Chappell; James F Meaney; Rose Anne Kenny Journal: Neurobiol Aging Date: 2021-04-22 Impact factor: 4.673