Literature DB >> 33454381

Biomaterial-based extracellular vesicle delivery for therapeutic applications.

Vishnu Priya Murali1, Christina A Holmes2.   

Abstract

Extracellular vesicle (EV)- based therapies have been successfully tested in preclinical models for several biomedical applications, including tissue engineering, drug delivery and cancer therapy. However, EVs are most commonly delivered via local or systemic injection, which results in rapid clearance. In order to prolong the retention of EVs at target site and improve their therapeutic efficacy, biomaterial-based delivery systems are being investigated. This review discusses the various biomaterial-based systems that have been used to deliver EVs for therapeutic applications, specifically highlighting any strategies for controlled release. Further, challenges to clinical translation of biomaterial-based EV delivery systems are also discussed.
Copyright © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Biomaterials; Drug delivery; Extracellular vesicles; Regenerative medicine; Tissue engineering

Mesh：

Substances：

Year:  2021        PMID： 33454381     DOI： 10.1016/j.actbio.2021.01.010

Source DB:  PubMed          Journal:  Acta Biomater        ISSN： 1742-7061            Impact factor:   8.947


  10 in total

1.  HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction.

Authors:  Qingjie Wang; Le Zhang; Zhiqin Sun; Boyu Chi; Ailin Zou; Lipeng Mao; Xu Xiong; JianGuang Jiang; Ling Sun; Wenwu Zhu; Yuan Ji
Journal:  Mater Today Bio       Date:  2021-11-27

Review 2.  Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics.

Authors:  Bohan Yin; Junguo Ni; Claire E Witherel; Mo Yang; Jason A Burdick; Chunyi Wen; Siu Hong Dexter Wong
Journal:  Theranostics       Date:  2022-01-01       Impact factor: 11.600

Review 3.  Diagnostic and Therapeutic Potential of Extracellular Vesicles.

Authors:  Sai Priyanka Kodam; Mujib Ullah
Journal:  Technol Cancer Res Treat       Date:  2021 Jan-Dec

Review 4.  Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies.

Authors:  Hong Wang; Yu Zheng; Qiang Sun; Zhen Zhang; Mengnan Zhao; Cheng Peng; Sanjun Shi
Journal:  J Nanobiotechnology       Date:  2021-10-15       Impact factor: 10.435

Review 5.  Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment.

Authors:  Yuanxin Xu; Kuanhan Feng; Huacong Zhao; Liuqing Di; Lei Wang; Ruoning Wang
Journal:  Theranostics       Date:  2022-01-16       Impact factor: 11.556

6.  Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration.

Authors:  Yike Gao; Zuoying Yuan; Xiaojing Yuan; Zhuo Wan; Yingjie Yu; Qi Zhan; Yuming Zhao; Jianmin Han; Jianyong Huang; Chunyang Xiong; Qing Cai
Journal:  Bioact Mater       Date:  2022-02-01

7.  Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?

Authors:  Abd Kakhar Umar; Jittima Amie Luckanagul; James H Zothantluanga; Sriwidodo Sriwidodo
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-14

8.  Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.

Authors:  Zhiwei Liao; Wencan Ke; Hui Liu; Bide Tong; Kun Wang; Xiaobo Feng; Wenbin Hua; Bingjin Wang; Yu Song; Rongjin Luo; Huaizhen Liang; Weifeng Zhang; Kangcheng Zhao; Shuai Li; Cao Yang
Journal:  J Nanobiotechnology       Date:  2022-09-19       Impact factor: 9.429

Review 9.  Clickable Biomaterials for Modulating Neuroinflammation.

Authors:  Chase Cornelison; Sherly Fadel
Journal:  Int J Mol Sci       Date:  2022-07-31       Impact factor: 6.208

10.  Mesenchymal Stem Cells Do Not Lose Direct Labels Including Iron Oxide Nanoparticles and DFO-89Zr Chelates through Secretion of Extracellular Vesicles.

Authors:  Yue Gao; Anna Jablonska; Chengyan Chu; Piotr Walczak; Miroslaw Janowski
Journal:  Membranes (Basel)       Date:  2021-06-29
  10 in total

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