Literature DB >> 3345438

Disinhibition in the rat septum mediated by M1 muscarinic receptors.

H Hasuo1, J P Gallagher, P Shinnick-Gallagher.   

Abstract

Acetylcholine (ACh) has been documented as an important central neurotransmitter. We have investigated the actions of ACh within the dorsolateral septal nucleus of the rat to examine its actions within this nucleus, specifically how it may interact to modulate the inhibitory action of gamma-aminobutyric acid (GABA), the known inhibitory transmitter in this area. Our results demonstrate that ACh, acting on M1 muscarinic receptors leads to disinhibition by decreasing GABA release.

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Year:  1988        PMID： 3345438     DOI： 10.1016/0006-8993(88)91356-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.

Authors:  S Sugita; N Uchimura; Z G Jiang; R A North
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

2.  Pharmacology of nicotinic receptor-mediated inhibition in rat dorsolateral septal neurones.

Authors:  L A Wong; J P Gallagher
Journal:  J Physiol       Date:  1991-05       Impact factor: 5.182

3.  Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma x glioma hybrid (NG 108-15) cells.

Authors:  M P Caulfield; D A Brown
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

4.  Muscarinic responses of rat basolateral amygdaloid neurons recorded in vitro.

Authors:  M S Washburn; H C Moises
Journal:  J Physiol       Date:  1992-04       Impact factor: 5.182
  4 in total

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