Ultrasensitive simultaneous voltammetric determination of 4-aminophenol and acetaminophen based on bimetallic MOF-derived nitrogen-doped carbon coated CoNi alloy.

Simultaneous electrochemical determination of 4-aminophenol (4-AP) and acetaminophen (ACOP) is crucial due to their high toxicity when are overused. Herein, a novel electrocatalyst of nitrogen-doped carbon coated CoNi alloy (CoNi@CN) is derived from bimetallic CoNi(BDC)2(DABCO) for the first time. A series of characterizations demonstrate that composite has been successfully synthesized, and all elements are evenly distributed in the catalyst. The optimal sensor based on Co1Ni1@CN-700 exhibits two wide linear responses for 4-AP (0.05-60 μM and 60-250 μM) and ACOP (0.05-40 μM and 40-150 μM) with the lowest detection limit of 5.2 nM and 3.8 nM compared with current known reports. Moreover, the sensor has superior reproducibility, selectivity and stability. In addition, the wonderful recoveries also are obtained when sensor is used to detect 4-AP and ACOP in real samples, illustrating that electrochemical sensor has great prospect in the clinical application.