Literature DB >> 33453413

Challenge to overcome current limitations of cell-penetrating peptides.

Gyu Chan Kim1, Dae Hee Cheon1, Yan Lee2.   

Abstract

The penetration of biological membranes is a prime obstacle for the delivery of pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver various cargos across the biological membranes. Since the discovery, CPPs have been rigorously studied to unveil the underlying penetrating mechanism as well as to exploit CPPs for various biomedical applications. This review will focus on the various strategies to overcome current limitations regarding stability, selectivity, and efficacy of CPPs.
Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords:  Antimicrobial peptides (AMPs); Cell penetrating peptides (CPPs); Drug delivery; Penetrating mechanism; Therapeutic applications

Year:  2021        PMID： 33453413     DOI： 10.1016/j.bbapap.2021.140604

Source DB:  PubMed          Journal:  Biochim Biophys Acta Proteins Proteom        ISSN： 1570-9639            Impact factor:   3.036


  13 in total

1.  Strategies for Peptide-Mediated Cargo Delivery to Human Smooth Muscle Cells.

Authors:  Leo Gurney; Stephen C Robson; Michèle Sweeney; Arwyn T Jones; Michael J Taggart
Journal:  Methods Mol Biol       Date:  2022

Review 2.  Cell-Penetrating Peptides as Passive Permeation Enhancers for Transdermal Drug Delivery.

Authors:  Lipika Chablani; Vijay Singh
Journal:  AAPS PharmSciTech       Date:  2022-09-26       Impact factor: 4.026

3.  Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation.

Authors:  Alfredo E Cardenas; Chad I Drexler; Rachel Nechushtai; Ron Mittler; Assaf Friedler; Lauren J Webb; Ron Elber
Journal:  J Phys Chem B       Date:  2022-04-07       Impact factor: 3.466

Review 4.  Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System.

Authors:  Ildikó Szabó; Mo'ath Yousef; Dóra Soltész; Csaba Bató; Gábor Mező; Zoltán Bánóczi
Journal:  Pharmaceutics       Date:  2022-04-21       Impact factor: 6.525

Review 5.  The role of cell-penetrating peptides in potential anti-cancer therapy.

Authors:  Meiling Zhou; Xi Zou; Kexin Cheng; Suye Zhong; Yangzhou Su; Tao Wu; Yongguang Tao; Li Cong; Bin Yan; Yiqun Jiang
Journal:  Clin Transl Med       Date:  2022-05

Review 6.  Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters.

Authors:  Francesco Ciscato; Lavinia Ferrone; Ionica Masgras; Claudio Laquatra; Andrea Rasola
Journal:  Int J Mol Sci       Date:  2021-04-29       Impact factor: 5.923

7.  Dipeptidyl Peptidase IV Inhibitory Peptides Generated in Dry-Cured Pork Loin during Aging and Gastrointestinal Digestion.

Authors:  Paulina Kęska; Joanna Stadnik
Journal:  Nutrients       Date:  2022-02-11       Impact factor: 5.717

8.  Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity.

Authors:  Donghui Zhang; Chao Shi; Zihao Cong; Qi Chen; Yufang Bi; Junyu Zhang; Kaiqian Ma; Shiqi Liu; Jiawei Gu; Minzhang Chen; Ziyi Lu; Haodong Zhang; Jiayang Xie; Ximian Xiao; Longqiang Liu; Weinan Jiang; Ning Shao; Sheng Chen; Min Zhou; Xiaoyan Shao; Yidong Dai; Maoquan Li; Lixin Zhang; Runhui Liu
Journal:  Adv Sci (Weinh)       Date:  2022-03-20       Impact factor: 17.521

9.  Hybrid Cyclobutane/Proline-Containing Peptidomimetics: The Conformational Constraint Influences Their Cell-Penetration Ability.

Authors:  Ona Illa; Jimena Ospina; José-Emilio Sánchez-Aparicio; Ximena Pulido; María Ángeles Abengozar; Nerea Gaztelumendi; Daniel Carbajo; Carme Nogués; Luis Rivas; Jean-Didier Maréchal; Miriam Royo; Rosa M Ortuño
Journal:  Int J Mol Sci       Date:  2021-05-11       Impact factor: 5.923

Review 10.  Method Development Progress in Genetic Engineering of Thraustochytrids.

Authors:  E-Ming Rau; Helga Ertesvåg
Journal:  Mar Drugs       Date:  2021-09-11       Impact factor: 5.118
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