| Literature DB >> 33452991 |
A S Sotnichenko1, I V Gilevich2,3, K I Melkonyan2, Y A Yutskevich2, T V Rusinova2, A V Karakulev2,3, S B Bogdanov2,3, V A Aladina2,3, Yu A Belich2, S E Gumenyuk2, D I Ushmarov2, I M Bykov2, A N Redko2, V A Porhanov2,3, S N Alekseenko2.
Abstract
The tissue reaction of pig skin to implantation of decellularized and recellularized dermal matrices on a formed wound defect was evaluated by histological methods on days 2, 5, 8, 16, and 20 after surgery. Differences in tissue response to different matrices were identified. In experimental wounds coated with decellularized dermal matrices, we observed the formation of a scar tissue, which required autodermoplasty on day 12 of the experiment. In wounds coated with recellularized dermal matrices, all layers of the skin completely recovered by day 20 after surgery with the formation of full dermal and epidermal layers. Our findings suggest that reparative morphological changes in the wound depend on the presence of fibroblasts in the implanted dermal matrix.Entities:
Keywords: biological scaffolds; decellularization; skin; tissue engineering
Year: 2021 PMID： 33452991 DOI： 10.1007/s10517-021-05071-0
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804