Literature DB >> 33452980

Studies of Molecular Mechanisms Underlying Cardioprotective Action of the ALM-802 Compound.

L M Kozhevnikova1,2, V V Barchukov1, N P Semenova2, M B Vititnova3, S A Kryzhanovskii1.   

Abstract

The mechanisms underlying cardioprotective activity of compound ALM-802 were studied in experiments on rats with chronic post-infarction heart failure. Real-time PCR showed that compound ALM-802 (daily intraperitoneal injections in a dose of 2 mg/kg for 28 days starting from day 91 after myocardial infarction modeling) restored the expression of genes encoding β1- (p=0.00001) and β2-adrenoreceptors (p=0.01) and type 2 ryanodine receptors (p=0.008) in the myocardium that was reduced in control animals. These effects can serve as the basis for the ability of the compound to reduce the intensity of remodeling and increase the inotropic function of the left heart ventricle shown earlier in this model.

Entities:  

Keywords:  ALM-802 compound; RyR2, IP3R2 and Ерас1; chronic heart failure; expression of mRNA β1- and β2-adrenergic receptors genes

Year:  2021        PMID： 33452980     DOI： 10.1007/s10517-021-05058-x

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  11 in total

1.  The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes.

Authors:  Laetitia Pereira; Mélanie Métrich; María Fernández-Velasco; Alexandre Lucas; Jérôme Leroy; Romain Perrier; Eric Morel; Rodolphe Fischmeister; Sylvain Richard; Jean-Pierre Bénitah; Frank Lezoualc'h; Ana María Gómez
Journal:  J Physiol       Date:  2007-06-28       Impact factor: 5.182

2.  Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.

Authors:  Emily A Oestreich; Huan Wang; Sundeep Malik; Katherine A Kaproth-Joslin; Burns C Blaxall; Grant G Kelley; Robert T Dirksen; Alan V Smrcka
Journal:  J Biol Chem       Date:  2006-12-17       Impact factor: 5.157

Review 3.  Metabolic remodelling in heart failure.

Authors:  Edoardo Bertero; Christoph Maack
Journal:  Nat Rev Cardiol       Date:  2018-08       Impact factor: 32.419

Review 4.  Arrhythmogenic and metabolic remodelling of failing human heart.

Authors:  C R Gloschat; A C Koppel; K K Aras; J A Brennan; K M Holzem; I R Efimov
Journal:  J Physiol       Date:  2016-06-12       Impact factor: 5.182

Review 5.  Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failure.

Authors:  Yuri M Lopatin; Giuseppe M C Rosano; Gabriele Fragasso; Gary D Lopaschuk; Petar M Seferovic; Luis Henrique W Gowdak; Dragos Vinereanu; Magdy Abdel Hamid; Patrick Jourdain; Piotr Ponikowski
Journal:  Int J Cardiol       Date:  2015-11-07       Impact factor: 4.164

Review 6.  Myocardial beta-1 adrenoceptor down-regulation in aging and heart failure: implications for beta-blocker use in older adults with heart failure.

Authors:  Ali Ahmed
Journal:  Eur J Heart Fail       Date:  2003-12       Impact factor: 15.534

7.  Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes.

Authors:  Hideaki Tagashira; Md Shenuarin Bhuiyan; Kohji Fukunaga
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-08-09       Impact factor: 4.733

8.  The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.

Authors:  Hiroyuki Nakayama; Ilona Bodi; Marjorie Maillet; Jaime DeSantiago; Timothy L Domeier; Katsuhiko Mikoshiba; John N Lorenz; Lothar A Blatter; Donald M Bers; Jeffery D Molkentin
Journal:  Circ Res       Date:  2010-07-08       Impact factor: 17.367

Review 9.  Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches.

Authors:  Felix Hohendanner; Andrew D McCulloch; Lothar A Blatter; Anushka P Michailova
Journal:  Front Pharmacol       Date:  2014-03-06       Impact factor: 5.810

Review 10.  Metabolic Coordination of Physiological and Pathological Cardiac Remodeling.

Authors:  Andrew A Gibb; Bradford G Hill
Journal:  Circ Res       Date:  2018-06-22       Impact factor: 17.367
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