Tao Ai1, Ronghua Luo2, Lei Zhang2, Li Wang2, Huiling Liao2, Yinghong Fan2, Yaping Duan2, Yijie Huang2. 1. Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617, Section 1, Riyue Avenue, Qingyang District, Chengdu City, Sichuan Province, China. ait1108@163.com. 2. Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617, Section 1, Riyue Avenue, Qingyang District, Chengdu City, Sichuan Province, China.
Abstract
OBJECTIVE: To investigate the fractional exhaled nitric oxide (FeNO) normal value of healthy children, and provide a reliable theoretical basis for clinical diagnosis. METHODS: 481 healthy children aged 6-15-y-old in three primary schools in Chengdu were subjected for FeNO detection. Through the statistical analysis, the upper limit normal value of FeNO among the healthy children was obtained, and the related influencing factors of FeNO value were analyzed. RESULTS: Among the 481 heathy children, the geometric mean value of FeNO was 14.59 ppb (minimum value was 5 ppb, maximum value was 69 ppb), and the upper limit of normal value was 28 ppb. The age, height, and weight all have significant correlations with FeNO. CONCLUSION: The upper limit of FeNO in healthy children aged 6-15-y-old was 28.0 ppb. Inflammation in the airway was suggested when the value of FeNO exceeds 28.0 ppb. Furthermore, the influencing factors such as age, weight, height must be considered.
OBJECTIVE: To investigate the fractional exhaled nitric oxide (FeNO) normal value of healthy children, and provide a reliable theoretical basis for clinical diagnosis. METHODS: 481 healthy children aged 6-15-y-old in three primary schools in Chengdu were subjected for FeNO detection. Through the statistical analysis, the upper limit normal value of FeNO among the healthy children was obtained, and the related influencing factors of FeNO value were analyzed. RESULTS: Among the 481 heathy children, the geometric mean value of FeNO was 14.59 ppb (minimum value was 5 ppb, maximum value was 69 ppb), and the upper limit of normal value was 28 ppb. The age, height, and weight all have significant correlations with FeNO. CONCLUSION: The upper limit of FeNO in healthy children aged 6-15-y-old was 28.0 ppb. Inflammation in the airway was suggested when the value of FeNO exceeds 28.0 ppb. Furthermore, the influencing factors such as age, weight, height must be considered.
Authors: Marta Czubaj-Kowal; Grzegorz Józef Nowicki; Ryszard Kurzawa; Maciej Polak; Barbara Ślusarska Journal: Medicina (Kaunas) Date: 2022-01-18 Impact factor: 2.430