| Literature DB >> 33450870 |
Youssof Eshac1, Rachel L Redfern2, Vinay Kumar Aakalu3.
Abstract
The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus on antimicrobial peptides and the role they play in the immune response of the ocular surface during healthy states and dry eye diseases. Antimicrobial peptides are of special interest to the study of the ocular surface because of their various roles that include microbial threat neutralization, wound healing, and immune modulation. This review explores current literature on antimicrobial peptides in ocular surface diseases and discusses their therapeutic potential in ocular surface diseases and dry eye.Entities:
Keywords: antimicrobial peptide; dry eye disease; innate immune system; ocular surface disease
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Year: 2021 PMID： 33450870 PMCID： PMC7828360 DOI： 10.3390/ijms22020721
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923