Background: SARS-CoV-2 is the new virus, and Streptococcus pneumoniae is one of the most important pathogens affecting humans. However, we do not yet know whether these microorganisms interact. Thus, we aimed to evaluate the relationship between Streptococcus pneumoniae and SARS-CoV-2 in pediatric patients. Methods: This study was conducted retrospectively by means of medical records of pediatric patients who were tested for SARS-CoV-2 between March 11 and June 04, 2020, in the University of Health Sciences, Ankara Educating and Training Hospital and Hacettepe University Faculty of Medicine. Results: We evaluated 829 pediatric patients for S. pneumoniae and SARS-CoV-2 from their nasopharyngeal specimen. Of 115 children positive for SARS-CoV-2, 32.2% had a positive S. pneumoniae test, whereas of 714 children negative for SARS-CoV-2, 14.1% had a positive S. pneumoniae test (p < .01). We compared patients with positive vs. negative SARS-CoV-2 tests according to S. pneumoniae positivity There were no statistically significant differences in terms of gender, underlying disease, fever, cough, leukocytosis, lymphopenia, increased CRP, increased procalcitonin, findings of chest x-ray, severity of disease, and treatment. Conclusion: The nasopharyngeal S. pneumoniae carriage rate in patients with COVID-19 was higher than in non-infected children, while S. pneumoniae carriage did not affect the course of COVID-19 disease. Pneumococcal vaccination is significant, such that we do not know the outcomes of increased pneumococcal carriage for the upcoming months of pandemic.
Background: SARS-CoV-2 is the new virus, and Streptococcus pneumoniae is one of the most important pathogens affecting humans. However, we do not yet know whether these microorganisms interact. Thus, we aimed to evaluate the relationship between Streptococcus pneumoniae and SARS-CoV-2 in pediatric patients. Methods: This study was conducted retrospectively by means of medical records of pediatric patients who were tested for SARS-CoV-2 between March 11 and June 04, 2020, in the University of Health Sciences, Ankara Educating and Training Hospital and Hacettepe University Faculty of Medicine. Results: We evaluated 829 pediatric patients for S. pneumoniae and SARS-CoV-2 from their nasopharyngeal specimen. Of 115 children positive for SARS-CoV-2, 32.2% had a positive S. pneumoniae test, whereas of 714 children negative for SARS-CoV-2, 14.1% had a positive S. pneumoniae test (p < .01). We compared patients with positive vs. negative SARS-CoV-2 tests according to S. pneumoniae positivity There were no statistically significant differences in terms of gender, underlying disease, fever, cough, leukocytosis, lymphopenia, increased CRP, increased procalcitonin, findings of chest x-ray, severity of disease, and treatment. Conclusion: The nasopharyngeal S. pneumoniae carriage rate in patients with COVID-19 was higher than in non-infected children, while S. pneumoniae carriage did not affect the course of COVID-19 disease. Pneumococcal vaccination is significant, such that we do not know the outcomes of increased pneumococcal carriage for the upcoming months of pandemic.
Authors: Birgit Simell; Kari Auranen; Helena Käyhty; David Goldblatt; Ron Dagan; Katherine L O'Brien Journal: Expert Rev Vaccines Date: 2012-07 Impact factor: 5.217
Authors: Xuan-Yi Wang; Paul E Kilgore; Kyung Ah Lim; Song-Mei Wang; Jeongseok Lee; Wei Deng; Mei-Qi Mo; Batmunkh Nyambat; Jing-Chen Ma; Michael O Favorov; John D Clemens Journal: Interdiscip Perspect Infect Dis Date: 2011-05-11
Authors: Xiaoli Tian; Feng Xu; Wing Yi Lung; Cherise Meyerson; Amir Ali Ghaffari; Genhong Cheng; Jane C Deng Journal: PLoS One Date: 2012-09-04 Impact factor: 3.240
Authors: Amber M Smith; Frederick R Adler; Ruy M Ribeiro; Ryan N Gutenkunst; Julie L McAuley; Jonathan A McCullers; Alan S Perelson Journal: PLoS Pathog Date: 2013-03-21 Impact factor: 6.823
Authors: Susan C Morpeth; Patrick Munywoki; Laura L Hammitt; Anne Bett; Christian Bottomley; Clayton O Onyango; David R Murdoch; D James Nokes; J Anthony G Scott Journal: Sci Rep Date: 2018-07-23 Impact factor: 4.379
Authors: Jorge E Vidal; Meagan N Wier; Uriel A Angulo-Zamudio; Erin McDevitt; Ana G Jop Vidal; Babek Alibayov; Anna Scasny; Sandy M Wong; Brian J Akerley; Larry S McDaniel Journal: Infect Immun Date: 2021-09-20 Impact factor: 3.441
Authors: Madeleine W Sumner; Alicia Kanngiesser; Kosar Lotfali-Khani; Nidhi Lodha; Diane Lorenzetti; Anna L Funk; Stephen B Freedman Journal: Front Pediatr Date: 2022-06-09 Impact factor: 3.569
Authors: Muntsa Rocafort; Desiree Henares; Pedro Brotons; Cristian Launes; Mariona Fernandez de Sevilla; Victoria Fumado; Irene Barrabeig; Sara Arias; Alba Redin; Julia Ponomarenko; Maria Mele; Pere Millat-Martinez; Joana Claverol; Nuria Balanza; Alex Mira; Juan J Garcia-Garcia; Quique Bassat; Iolanda Jordan; Carmen Muñoz-Almagro Journal: Viruses Date: 2022-07-12 Impact factor: 5.818