Literature DB >> 3344788

Negative antibody response to long-term treatment of facial spasm with botulinum toxin.

R S Gonnering1.   

Abstract

Over a period of 163 weeks, 223 injections of botulinum A toxin were administered to 38 patients with facial spasm syndromes. The maximum cumulative toxin dose was 553 units, the maximum number of injections in any given patient was 16, and the maximum dosage of any given injection was 52.5 units. Sera from these patients showed no antibody production when measured with a standard mouse lethality bioassay.

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Year:  1988        PMID: 3344788     DOI: 10.1016/0002-9394(88)90016-5

Source DB:  PubMed          Journal:  Am J Ophthalmol        ISSN: 0002-9394            Impact factor:   5.258


  4 in total

Review 1.  Clostridium botulinum toxins: a general review of involvement in disease, structure, mode of action and preparation for clinical use.

Authors:  P Hambleton
Journal:  J Neurol       Date:  1992-01       Impact factor: 4.849

2.  Treatment selections of 239 patients with blepharospasm and Meige syndrome over 11 years.

Authors:  J A Mauriello; S Dhillon; T Leone; B Pakeman; R Mostafavi; M C Yepez
Journal:  Br J Ophthalmol       Date:  1996-12       Impact factor: 4.638

3.  Botulinum toxin F in the treatment of torticollis clinically resistant to botulinum toxin A.

Authors:  G L Sheean; A J Lees
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-12       Impact factor: 10.154

Review 4.  [Antibody-induced failure of botulinum toxin therapy].

Authors:  D Dressler
Journal:  Nervenarzt       Date:  2003-12       Impact factor: 1.214

  4 in total

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