UNLABELLED: Sixteen patients with metastatic carcinoma of the pancreas were treated with continuous ambulatory 5-Fluorouracil (5FU) infusion (200-300 mg/m2/day) through a chronic indwelling central venous catheter. Twelve of sixteen patients (75%) had two or more sites of disease, and eleven of sixteen (69%) had liver metastases. Five patients had previous chemotherapy. RESULTS: partial remission, 3/16 (19%); stable disease, 8/16 (50%); and progressive disease, 5/16 (31%). Improvement in ECOG performance status was observed in 2/3 responding and 6/8 stable disease patients, respectively. Toxicities included hand-foot syndrome, mucositis, diarrhea, and cerebellar ataxia, which required treatment interruption in 9/16 patients (56%). No myelosuppression or catheter related problems were seen. The authors conclude that continuous infusion 5FU is a potentially efficacious palliative therapy in the management of carcinoma of the pancreas.
UNLABELLED: Sixteen patients with metastatic carcinoma of the pancreas were treated with continuous ambulatory 5-Fluorouracil (5FU) infusion (200-300 mg/m2/day) through a chronic indwelling central venous catheter. Twelve of sixteen patients (75%) had two or more sites of disease, and eleven of sixteen (69%) had liver metastases. Five patients had previous chemotherapy. RESULTS: partial remission, 3/16 (19%); stable disease, 8/16 (50%); and progressive disease, 5/16 (31%). Improvement in ECOG performance status was observed in 2/3 responding and 6/8 stable disease patients, respectively. Toxicities included hand-foot syndrome, mucositis, diarrhea, and cerebellar ataxia, which required treatment interruption in 9/16 patients (56%). No myelosuppression or catheter related problems were seen. The authors conclude that continuous infusion 5FU is a potentially efficacious palliative therapy in the management of carcinoma of the pancreas.
Authors: C Zanon; O Alabiso; M Grosso; R Buosi; I Chiappino; R Clara; A Satolli; S Zai; M Bortolini; M Botta; A Mussa Journal: Int J Pancreatol Date: 2000-06
Authors: J J Arends; H P Sleeboom; M B L Leys; D Ten Bokkel Huinink; R S de Jong; J M Smit; J W R Nortier; M E T Tesselaar Journal: Br J Cancer Date: 2005-02-14 Impact factor: 7.640
Authors: F Di Costanzo; P Carlini; L Doni; B Massidda; R Mattioli; A Iop; E Barletta; L Moscetti; F Recchia; P Tralongo; S Gasperoni Journal: Br J Cancer Date: 2005-07-25 Impact factor: 7.640
Authors: Rosa B Schmuck; Cynthia V de Carvalho-Fischer; Christopher Neumann; Johann Pratschke; Marcus Bahra Journal: Cancer Med Date: 2015-12-09 Impact factor: 4.452