Yuichi Tamura1, Hiraku Kumamaru2, Kohtaro Abe3, Toru Satoh4, Hiroaki Miyata2,5, Aiko Ogawa6, Nobuhiro Tanabe7, Masaru Hatano8, Atsushi Yao9, Ichizo Tsujino10, Keiichi Fukuda11, Hiroshi Kimura12, Masataka Kuwana13, Hiromi Matsubara6, Koichiro Tatsumi14. 1. Pulmonary Hypertension Center, International University of Health and Welfare Mita Hospital, Tokyo, Japan. u1@ta-mu.net. 2. Department of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 3. Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan. 4. Department of Cardiology, Kyorin University School of Medicine, Mitaka, Japan. 5. Department of Health Policy and Management, Keio University School of Medicine, Tokyo, Japan. 6. Department of Clinical Science, National Hospital Organization Okayama Medical Center, Okayama, Japan. 7. Pulmonary Hypertension Center, Chibaken Saiseikai Narashino Hospital, Narashino, Japan. 8. Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan. 9. Division for Health Service Promotion, The University of Tokyo, Tokyo, Japan. 10. First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan. 11. Department of Cardiology, Keio University School of Medicine, Tokyo, Japan. 12. Department of Pulmonary Medicine, Nippon Medical School Graduate School of Medicine, Tokyo, Japan. 13. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan. 14. Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Abstract
BACKGROUND: Since there was no previous report, we analyzed the relationship between French Risk Stratification parameters in pulmonary arterial hypertension (PAH) and mean pulmonary arterial pressures (mPAP) using Japan PH Registry (JAPHR) national-wide cohort. METHODS: We enrolled 108 patients with PAH from JAPHR from previous reported cohort and analyzed the relations between French Risk Stratification scores and hemodynamic improvements. RESULTS: The ratio meeting 0 to 4 French Risk Stratification score was 21.3%, 31.5%, 32.4%, 13.0%, and 1.9% at baseline, and 6.5%, 23.2%, 33.3%, 23.2%, 13.9% at follow-up, respectively. The improvements in the number of criteria met were associated both with mPAP at follow-up (p = 0.03) and with the improvements in mPAP (p < 0.001). CONCLUSION: The improvements in French Risk Stratification may become a marker of improved hemodynamics including mPAP.
BACKGROUND: Since there was no previous report, we analyzed the relationship between French Risk Stratification parameters in pulmonary arterial hypertension (PAH) and mean pulmonary arterial pressures (mPAP) using Japan PH Registry (JAPHR) national-wide cohort. METHODS: We enrolled 108 patients with PAH from JAPHR from previous reported cohort and analyzed the relations between French Risk Stratification scores and hemodynamic improvements. RESULTS: The ratio meeting 0 to 4 French Risk Stratification score was 21.3%, 31.5%, 32.4%, 13.0%, and 1.9% at baseline, and 6.5%, 23.2%, 33.3%, 23.2%, 13.9% at follow-up, respectively. The improvements in the number of criteria met were associated both with mPAP at follow-up (p = 0.03) and with the improvements in mPAP (p < 0.001). CONCLUSION: The improvements in French Risk Stratification may become a marker of improved hemodynamics including mPAP.
Authors: Nazzareno Galiè; Marc Humbert; Jean-Luc Vachiery; Simon Gibbs; Irene Lang; Adam Torbicki; Gérald Simonneau; Andrew Peacock; Anton Vonk Noordegraaf; Maurice Beghetti; Ardeschir Ghofrani; Miguel Angel Gomez Sanchez; Georg Hansmann; Walter Klepetko; Patrizio Lancellotti; Marco Matucci; Theresa McDonagh; Luc A Pierard; Pedro T Trindade; Maurizio Zompatori; Marius Hoeper Journal: Eur Respir J Date: 2015-08-29 Impact factor: 16.671