Literature DB >> 33445805

Machine Learning Algorithms Applied to Identify Microbial Species by Their Motility.

Max Riekeles1, Janosch Schirmack1, Dirk Schulze-Makuch1,2,3,4.   

Abstract

(1) Background: Future missions to potentially habitable places in the Solar System require biochemistry-independent methods for detecting potential alien life forms. The technology was not advanced enough for onboard machine analysis of microscopic observations to be performed in past missions, but recent increases in computational power make the use of automated in-situ analyses feasible. (2)
Methods: Here, we present a semi-automated experimental setup, capable of distinguishing the movement of abiotic particles due to Brownian motion from the motility behavior of the bacteria Pseudoalteromonas haloplanktis, Planococcus halocryophilus, Bacillus subtilis, and Escherichia coli. Supervised machine learning algorithms were also used to specifically identify these species based on their characteristic motility behavior. (3)
Results: While we were able to distinguish microbial motility from the abiotic movements due to Brownian motion with an accuracy exceeding 99%, the accuracy of the automated identification rates for the selected species does not exceed 82%. (4) Conclusions: Motility is an excellent biosignature, which can be used as a tool for upcoming life-detection missions. This study serves as the basis for the further development of a microscopic life recognition system for upcoming missions to Mars or the ocean worlds of the outer Solar System.

Entities:  

Keywords:  automation; biosignature; life detection; machine learning; motility; species identification

Year:  2021        PMID: 33445805      PMCID: PMC7828299          DOI: 10.3390/life11010044

Source DB:  PubMed          Journal:  Life (Basel)        ISSN: 2075-1729


  13 in total

1.  Planococcus halocryophilus sp. nov., an extreme sub-zero species from high Arctic permafrost.

Authors:  Nadia C S Mykytczuk; Roland C Wilhelm; Lyle G Whyte
Journal:  Int J Syst Evol Microbiol       Date:  2011-10-14       Impact factor: 2.747

Review 2.  Bacterial motility: links to the environment and a driving force for microbial physics.

Authors:  James G Mitchell; Kazuhiro Kogure
Journal:  FEMS Microbiol Ecol       Date:  2006-01       Impact factor: 4.194

3.  Swimming in circles: motion of bacteria near solid boundaries.

Authors:  Eric Lauga; Willow R DiLuzio; George M Whitesides; Howard A Stone
Journal:  Biophys J       Date:  2005-10-20       Impact factor: 4.033

Review 4.  The structure and regulation of flagella in Bacillus subtilis.

Authors:  Sampriti Mukherjee; Daniel B Kearns
Journal:  Annu Rev Genet       Date:  2014-09-10       Impact factor: 16.830

5.  Temperature effects on bacterial movement.

Authors:  W R Schneider; R N Doetsch
Journal:  Appl Environ Microbiol       Date:  1977-12       Impact factor: 4.792

6.  Fed-batch process for the psychrotolerant marine bacterium Pseudoalteromonas haloplanktis.

Authors:  Boris Wilmes; Angelika Hartung; Michael Lalk; Manuel Liebeke; Thomas Schweder; Peter Neubauer
Journal:  Microb Cell Fact       Date:  2010-09-21       Impact factor: 5.328

Review 7.  Motility.

Authors:  R D Allen
Journal:  J Cell Biol       Date:  1981-12       Impact factor: 10.539

8.  Bacillus subtilis: from soil bacterium to super-secreting cell factory.

Authors:  Jan Maarten van Dijl; Michael Hecker
Journal:  Microb Cell Fact       Date:  2013-01-14       Impact factor: 5.328

9.  A Submersible, Off-Axis Holographic Microscope for Detection of Microbial Motility and Morphology in Aqueous and Icy Environments.

Authors:  Christian A Lindensmith; Stephanie Rider; Manuel Bedrossian; J Kent Wallace; Eugene Serabyn; G Max Showalter; Jody W Deming; Jay L Nadeau
Journal:  PLoS One       Date:  2016-01-26       Impact factor: 3.240

10.  High-throughput 3D tracking of bacteria on a standard phase contrast microscope.

Authors:  K M Taute; S Gude; S J Tans; T S Shimizu
Journal:  Nat Commun       Date:  2015-11-02       Impact factor: 14.919

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  1 in total

1.  Quantification of Motility in Bacillus subtilis at Temperatures Up to 84°C Using a Submersible Volumetric Microscope and Automated Tracking.

Authors:  Megan M Dubay; Nikki Johnston; Mark Wronkiewicz; Jake Lee; Christian A Lindensmith; Jay L Nadeau
Journal:  Front Microbiol       Date:  2022-04-21       Impact factor: 6.064

  1 in total

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