| Literature DB >> 33445521 |
Olesya I Zhuravleva1,2, Alexandr S Antonov1, Vo Thi Dieu Trang3, Mikhail V Pivkin1, Yuliya V Khudyakova1, Vladimir A Denisenko1, Roman S Popov1, Natalya Y Kim1, Ekaterina A Yurchenko1, Andrey V Gerasimenko4, Anatoly A Udovenko4, Gunhild von Amsberg5,6, Sergey A Dyshlovoy1,2,5,6, Shamil S Afiyatullov1.
Abstract
Seven new deoxyisoaustamide derivatives (1-7) together with known compounds (8-10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4-6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30-39%.Entities:
Keywords: Penicillium dimorphosporum; deoxyisoaustamide; neuroprotective activity; paraquat; prenylated indole diketopiperazines; secondary metabolites
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Year: 2021 PMID： 33445521 PMCID： PMC7826743 DOI： 10.3390/md19010032
Source DB: PubMed Journal: Mar Drugs ISSN： 1660-3397 Impact factor: 5.118