Olesya I Zhuravleva1,2, Alexandr S Antonov1, Vo Thi Dieu Trang3, Mikhail V Pivkin1, Yuliya V Khudyakova1, Vladimir A Denisenko1, Roman S Popov1, Natalya Y Kim1, Ekaterina A Yurchenko1, Andrey V Gerasimenko4, Anatoly A Udovenko4, Gunhild von Amsberg5,6, Sergey A Dyshlovoy1,2,5,6, Shamil S Afiyatullov1. 1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. 2. School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, 690000 Vladivostok, Russia. 3. Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam. 4. Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. 5. Laboratory of Experimental Oncology, Department of Oncology, University Medical Center Hamburg-Eppendorf, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, 20246 Hamburg, Germany. 6. Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany.
Abstract
Seven new deoxyisoaustamide derivatives (1-7) together with known compounds (8-10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4-6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30-39%.
Seven new deoxyisoaustamide derivatives (1-7) together with known compounds (8-10) were isolated from the coral-derived fungus n class="Species">Penicillium dimorphosporumKMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4-6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30-39%.
Authors: Sergey A Dyshlovoy; Dmitry N Pelageev; Jessica Hauschild; Ksenia L Borisova; Moritz Kaune; Christoph Krisp; Simone Venz; Yurii E Sabutskii; Ekaterina A Khmelevskaya; Tobias Busenbender; Vladimir A Denisenko; Natalia D Pokhilo; Lyubov N Atopkina; Markus Graefen; Hartmut Schlüter; Valentin A Stonik; Carsten Bokemeyer; Victor Ph Anufriev; Gunhild von Amsberg Journal: Cancers (Basel) Date: 2019-10-30 Impact factor: 6.639
Authors: Ekaterina A Yurchenko; Ekaterina S Menchinskaya; Evgeny A Pislyagin; Ekaterina A Chingizova; Elena V Girich; Anton N Yurchenko; Dmitry L Aminin; Valery V Mikhailov Journal: Molecules Date: 2021-06-13 Impact factor: 4.411