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Literature DB >> 33445129

Protein N-glycosylation and O-mannosylation are catalyzed by two evolutionarily related GT-C glycosyltransferases.

Abstract

The structural folds of glycosyltransferases are categorized into three superfamilies: GT-A, GT-B, and GT-C. Few structures of GT-C fold existed in the Protein Data Bank prior to the recent advent of high-resolution cryo-EM, because the glycosyltransferases are large membrane proteins that are difficult to crystallize. The use of cryo-EM has resulted in the structures of several key GT-C glycosyltransferases. Here we summarize the latest structural features of and mechanistic insights into these membrane enzyme complexes.

Entities: Chemical

Mesh：

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Year: 2021 PMID： 33445129 PMCID： PMC8222153 DOI： 10.1016/j.sbi.2020.12.009

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 7.786

43 in total

Review 1. Protein O-mannosylation: what we have learned from baker's yeast.

Authors: Martin Loibl; Sabine Strahl
Journal: Biochim Biophys Acta Date: 2013-02-20

2. Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.

Authors: Aixin Yan; William J Lennarz
Journal: Glycobiology Date: 2005-08-11 Impact factor: 4.313

Review 3. N-linked glycosylation and homeostasis of the endoplasmic reticulum.

Authors: Natalia Cherepanova; Shiteshu Shrimal; Reid Gilmore
Journal: Curr Opin Cell Biol Date: 2016-04-14 Impact factor: 8.382

Review 4. Dolichol-phosphate mannose synthase: structure, function and regulation.

Authors: Yusuke Maeda; Taroh Kinoshita
Journal: Biochim Biophys Acta Date: 2008-03-14

Review 5. Roles of N-linked glycans in the endoplasmic reticulum.

Authors: Ari Helenius; Markus Aebi
Journal: Annu Rev Biochem Date: 2004 Impact factor: 23.643

Review 6. Glycosyltransferases: structures, functions, and mechanisms.

Authors: L L Lairson; B Henrissat; G J Davies; S G Withers
Journal: Annu Rev Biochem Date: 2008 Impact factor: 23.643

7. Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

Authors: Natalia A Cherepanova; Shiteshu Shrimal; Reid Gilmore
Journal: J Cell Biol Date: 2014-08-18 Impact factor: 10.539

8. Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB₂-AcpM₂.

Authors: Lu Zhang; Yao Zhao; Ruogu Gao; Jun Li; Xiuna Yang; Yan Gao; Wei Zhao; Sudagar S Gurcha; Natacha Veerapen; Sarah M Batt; Kajelle Kaur Besra; Wenqing Xu; Lijun Bi; Xian'en Zhang; Luke W Guddat; Haitao Yang; Quan Wang; Gurdyal S Besra; Zihe Rao
Journal: Protein Cell Date: 2020-05-03 Impact factor: 14.870

2. Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.

Authors: Chris Hadjineophytou; Jan Haug Anonsen; Tina Svingerud; Tatum D Mortimer; Yonatan H Grad; Nichollas E Scott; Michael Koomey
Journal: mBio Date: 2022-04-26 Impact factor: 7.786

2 in total

Protein N-glycosylation and O-mannosylation are catalyzed by two evolutionarily related GT-C glycosyltransferases.

Review 1. Protein O-mannosylation: what we have learned from baker's yeast.

2. Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.

Review 3. N-linked glycosylation and homeostasis of the endoplasmic reticulum.

Review 4. Dolichol-phosphate mannose synthase: structure, function and regulation.

Review 5. Roles of N-linked glycans in the endoplasmic reticulum.

Review 6. Glycosyltransferases: structures, functions, and mechanisms.

7. Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

8. Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB₂-AcpM₂.

9. Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.

10. Structure of the native Sec61 protein-conducting channel.

Review 1. Structural variations and roles of rhamnose-rich cell wall polysaccharides in Gram-positive bacteria.

2. Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.

Protein N-glycosylation and O-mannosylation are catalyzed by two evolutionarily related GT-C glycosyltransferases.

Review 1. Protein O-mannosylation: what we have learned from baker's yeast.

2. Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.

Review 3. N-linked glycosylation and homeostasis of the endoplasmic reticulum.

Review 4. Dolichol-phosphate mannose synthase: structure, function and regulation.

Review 5. Roles of N-linked glycans in the endoplasmic reticulum.

Review 6. Glycosyltransferases: structures, functions, and mechanisms.

7. Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

8. Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2.

9. Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.

10. Structure of the native Sec61 protein-conducting channel.

Review 1. Structural variations and roles of rhamnose-rich cell wall polysaccharides in Gram-positive bacteria.

2. Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.

8. Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB₂-AcpM₂.