| Literature DB >> 33443534 |
Haomeng Zhang1, Jiao Wang2, Yulong Yin1, Qingjie Meng1, Yonggang Lyu1.
Abstract
Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epithelial-mesenchymal transition (EMT). Recent studies have shown that long non-coding RNA (LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the molecular mechanism of TNBC metastasis, which will provide new strategies to improve the treatment and prognosis of TNBC. In this review, we summarized many signal pathways related to EMT involved in the transfer process. The advances from the most recent studies of lncRNAs in the EMT-related signal pathways of TNBC metastasis. We also discussed the clinical research, application, and challenges of LncRNA in TNBC.Entities:
Keywords: Epithelial-mesenchymal transition(EMT); Metastasis; Triple-negative breast cancer(TNBC); long non-coding RNA(LncRNA)
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Year: 2021 PMID： 33443534 PMCID： PMC7859322 DOI： 10.1042/BSR20203121
Source DB: PubMed Journal: Biosci Rep ISSN： 0144-8463 Impact factor: 3.840