| Literature DB >> 33442687 |
Jennifer M Dan1,2, Jose Mateus1, Yu Kato1, Kathryn M Hastie1, Esther Dawen Yu1, Caterina E Faliti1, Alba Grifoni1, Sydney I Ramirez1,2, Sonya Haupt1, April Frazier1, Catherine Nakao1, Vamseedhar Rayaprolu1, Stephen A Rawlings2, Bjoern Peters1,3, Florian Krammer4, Viviana Simon4,5,6, Erica Ollmann Saphire1,2, Davey M Smith2, Daniela Weiskopf1, Alessandro Sette1,2, Shane Crotty1,2.
Abstract
Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4 + T cells and CD8 + T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4 + T cell, and CD8 + T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.Entities:
Year: 2020 PMID： 33442687 PMCID： PMC7805444 DOI： 10.1101/2020.11.15.383323
Source DB: PubMed Journal: bioRxiv