Jian Zhou1, Huichuan Sun1, Zheng Wang1, Wenming Cong2, Jianhua Wang3, Mengsu Zeng4, Weiping Zhou5, Ping Bie6, Lianxin Liu7, Tianfu Wen8, Guohong Han9, Maoqiang Wang10, Ruibao Liu11, Ligong Lu12, Zhengang Ren1, Minshan Chen13, Zhaochong Zeng14, Ping Liang15, Changhong Liang16, Min Chen17, Fuhua Yan18, Wenping Wang19, Yuan Ji20, Jingping Yun21, Dingfang Cai22, Yongjun Chen23, Wenwu Cheng24, Shuqun Cheng5, Chaoliu Dai25, Wenzhi Guo26, Baojin Hua27, Xiaowu Huang1, Weidong Jia28, Yaming Li29, Yexiong Li30, Jun Liang31, Tianshu Liu32, Guoyue Lv33, Yilei Mao34, Tao Peng35, Weixin Ren36, Hongcheng Shi37, Guoming Shi1, Kaishan Tao38, Wentao Wang8, Xiaoying Wang1, Zhiming Wang39, Bangde Xiang40, Baocai Xing41, Jianming Xu42, Jiamei Yang5, Jianyong Yang43, Yefa Yang44, Yunke Yang22, Shenglong Ye1, Zhengyu Yin45, Bixiang Zhang46, Boheng Zhang1, Leida Zhang47, Shuijun Zhang48, Ti Zhang49, Yongfu Zhao48, Honggang Zheng50, Jiye Zhu51, Kangshun Zhu52, Rong Liu3, Yinghong Shi1, Yongsheng Xiao1, Zhi Dai1, Gaojun Teng53, Jianqiang Cai54, Weilin Wang55, Xiujun Cai56, Qiang Li49, Feng Shen5, Shukui Qin57, Jiahong Dong58, Jia Fan1. 1. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. 2. Department of Pathology, The Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. 3. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. 4. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. 5. The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. 6. Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China. 7. Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. 8. Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, China. 9. Department of Liver Diseases and Digestive Interventional Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. 10. Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, China. 11. Department of Interventional Radiology, The Tumor Hospital of Harbin Medical University, Harbin, China. 12. Department of Interventional Oncology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. 13. Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. 14. Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China. 15. Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China. 16. Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. 17. Editorial Department of Chinese Journal of Digestive Surgery, Chongqing, China. 18. Department of Radiology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. 19. Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China. 20. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China. 21. Department of Pathology, Tumor Prevention and Treatment Center, Sun Yat-sen University, Guangzhou, China. 22. Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. 23. Department of Hematology, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 24. Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China. 25. Department of Hepatobiliary and Spleenary Surgery, The Affiliated Shengjing Hospital, China Medical University, Shenyang, China. 26. Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 27. Graduate School, Beijing University of Chinese Medicine, Beijing, China. 28. Department of Hepatic Surgery, Affiliated Provincial Hospital, Anhui Medical University, Hefei, China. 29. Department of Nuclear Medicine, The First Hospital of China Medical University, Shenyang, China. 30. Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 31. Department of Oncology, Peking University International Hospital, Beijing, China. 32. Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China. 33. Department of General Surgery, The First Hospital of Jilin University, Jilin, China. 34. Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China. 35. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. 36. Department of Interventional Radiology The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. 37. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. 38. Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China. 39. Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China. 40. Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China. 41. Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, China. 42. Department of Gastrointestinal Oncology, Affiliated Hospital Cancer Center, Academy of Military Medical Sciences, Beijing, China. 43. Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 44. Department of Hepatic Surgery & Interventional Radiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. 45. Department of Hepatobiliary Surgery, Zhongshan Hospital of Xiamen University, Hubing South Road, Xiamen, China. 46. Department of Surgery, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 47. Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. 48. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, ZhengZhou, China. 49. Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. 50. Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. 51. Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China. 52. Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. 53. Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China. 54. Department of Abdominal Surgical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 55. Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 56. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. 57. Department of Medical Oncology, PLA Cancer Center, Nanjing Bayi Hospital, Nanjing, China. 58. Department of Hepatobiliary and Pancreas Surgery, Beijing Tsinghua Changgung Hospital (BTCH), School of Clinical Medicine, Tsinghua University, Beijing, China.
Abstract
BACKGROUND: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and the second leading cause of tumor-related death, thereby posing a significant threat to the life and health of the Chinese people. SUMMARY: Since the publication of Guidelines for Diagnosis and Treatment of Primary Liver Cancer (2017 Edition) in 2018, additional high-quality evidence has emerged with relevance to the diagnosis, staging, and treatment of liver cancer in and outside China that requires the guidelines to be updated. The new edition (2019 Edition) was written by more than 70 experts in the field of liver cancer in China. They reflect the real-world situation in China regarding diagnosing and treating liver cancer in recent years. KEY MESSAGES: Most importantly, the new guidelines were endorsed and promulgated by the Bureau of Medical Administration of the National Health Commission of the People's Republic of China in December 2019.
BACKGROUND: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and the second leading cause of tumor-related death, thereby posing a significant threat to the life and health of the Chinese people. SUMMARY: Since the publication of Guidelines for Diagnosis and Treatment of Primary Liver Cancer (2017 Edition) in 2018, additional high-quality evidence has emerged with relevance to the diagnosis, staging, and treatment of liver cancer in and outside China that requires the guidelines to be updated. The new edition (2019 Edition) was written by more than 70 experts in the field of liver cancer in China. They reflect the real-world situation in China regarding diagnosing and treating liver cancer in recent years. KEY MESSAGES: Most importantly, the new guidelines were endorsed and promulgated by the Bureau of Medical Administration of the National Health Commission of the People's Republic of China in December 2019.
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Authors: Andrew X Zhu; Yoon-Koo Kang; Chia-Jui Yen; Richard S Finn; Peter R Galle; Josep M Llovet; Eric Assenat; Giovanni Brandi; Marc Pracht; Ho Yeong Lim; Kun-Ming Rau; Kenta Motomura; Izumi Ohno; Philippe Merle; Bruno Daniele; Dong Bok Shin; Guido Gerken; Christophe Borg; Jean-Baptiste Hiriart; Takuji Okusaka; Manabu Morimoto; Yanzhi Hsu; Paolo B Abada; Masatoshi Kudo Journal: Lancet Oncol Date: 2019-01-18 Impact factor: 41.316