Literature DB >> 33440733

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond.

Zdeněk Kejík1,2,3, Robert Kaplánek1,2,3, Michal Masařík1,2,4,5, Petr Babula4, Adam Matkowski6, Petr Filipenský7, Kateřina Veselá1,2,3, Jakub Gburek8, David Sýkora1,3, Pavel Martásek1, Milan Jakubek1,2,3.   

Abstract

Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.

Entities:  

Keywords:  flavonoids; iron ions; metallocomplexes

Mesh：

Substances：

Year:  2021        PMID： 33440733      PMCID： PMC7827006          DOI： 10.3390/ijms22020646

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  131 in total

1.  Antioxidant effect of flavonoids after ascorbate/Fe(2+)-induced oxidative stress in cultured retinal cells.

Authors:  F M Areias; A C Rego; C R Oliveira; R M Seabra
Journal:  Biochem Pharmacol       Date:  2001-07-01       Impact factor: 5.858

Review 2.  Collagen Prolyl 4-Hydroxylase as a Therapeutic Target.

Authors:  James D Vasta; Ronald T Raines
Journal:  J Med Chem       Date:  2018-07-23       Impact factor: 7.446

3.  Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood.

Authors:  Daniela Ribeiro; Marisa Freitas; Sara M Tomé; Artur M S Silva; Stefan Laufer; José L F C Lima; Eduarda Fernandes
Journal:  Inflammation       Date:  2015-04       Impact factor: 4.092

Review 4.  Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms.

Authors:  Abigail J Larson; J David Symons; Thunder Jalili
Journal:  Adv Nutr       Date:  2012-01-05       Impact factor: 8.701

5.  Iron and copper chelation by flavonoids: an electrospray mass spectrometry study.

Authors:  M Tereza Fernandez; M Lurdes Mira; M Helena Florêncio; Keith R Jennings
Journal:  J Inorg Biochem       Date:  2002-11-11       Impact factor: 4.155

6.  [Partitioning of taxifolin-iron ions complexes in octanol-water system].

Authors:  Iu V Shatalin; V S Shubina
Journal:  Biofizika       Date:  2014 May-Jun

7.  Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity.

Authors:  Lurdes Mira; M Tereza Fernandez; Marta Santos; Rui Rocha; M Helena Florêncio; Keith R Jennings
Journal:  Free Radic Res       Date:  2002-11

8.  A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations.

Authors:  Giuseppe Grosso; Justyna Godos; Rosa Lamuela-Raventos; Sumantra Ray; Agnieszka Micek; Andrzej Pajak; Salvatore Sciacca; Nicolantonio D'Orazio; Daniele Del Rio; Fabio Galvano
Journal:  Mol Nutr Food Res       Date:  2017-02-07       Impact factor: 5.914

9.  Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide.

Authors:  Umeo Takahama; Takayuki Oniki; Sachiko Hirota
Journal:  J Agric Food Chem       Date:  2002-07-17       Impact factor: 5.279

10.  Hydrogen peroxide metabolism in human monocytes during differentiation in vitro.

Authors:  A Nakagawara; C F Nathan; Z A Cohn
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808
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  6 in total

Review 1.  A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights.

Authors:  Luana Malacaria; Giuseppina Anna Corrente; Amerigo Beneduci; Emilia Furia; Tiziana Marino; Gloria Mazzone
Journal:  Molecules       Date:  2021-04-29       Impact factor: 4.411

2.  Antioxidant vs. Prooxidant Properties of the Flavonoid, Kaempferol, in the Presence of Cu(II) Ions: A ROS-Scavenging Activity, Fenton Reaction and DNA Damage Study.

Authors:  Miriama Simunkova; Zuzana Barbierikova; Klaudia Jomova; Lenka Hudecova; Peter Lauro; Saleh H Alwasel; Ibrahim Alhazza; Christopher J Rhodes; Marian Valko
Journal:  Int J Mol Sci       Date:  2021-02-05       Impact factor: 5.923

Review 3.  Flavonoids in Treatment of Chronic Kidney Disease.

Authors:  Yi-Ling Cao; Ji-Hong Lin; Hans-Peter Hammes; Chun Zhang
Journal:  Molecules       Date:  2022-04-06       Impact factor: 4.411

4.  Interactions of Ascorbic Acid, 5-Caffeoylquinic Acid, and Quercetin-3-Rutinoside in the Presence and Absence of Iron during Thermal Processing and the Influence on Antioxidant Activity.

Authors:  Layla Engelhardt; Tobias Pöhnl; Susanne Neugart
Journal:  Molecules       Date:  2021-12-20       Impact factor: 4.411

Review 5.  The Effect of Antioxidant Added to Preservation Solution on the Protection of Kidneys before Transplantation.

Authors:  Aneta Ostróżka-Cieślik
Journal:  Int J Mol Sci       Date:  2022-03-15       Impact factor: 5.923

6.  A Major Diplotaxis harra-Derived Bioflavonoid Glycoside as a Protective Agent against Chemically Induced Neurotoxicity and Parkinson's Models; In Silico Target Prediction; and Biphasic HPTLC-Based Quantification.

Authors:  Atallah F Ahmed; Zhi-Hong Wen; Ahmed H Bakheit; Omer A Basudan; Hazem A Ghabbour; Abdullah Al-Ahmari; Chien-Wei Feng
Journal:  Plants (Basel)       Date:  2022-02-27
  6 in total

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