Literature DB >> 33440135

Spliceosome-Targeted Therapies Induce dsRNA Responses.

Charles A Ishak1, Helen Loo Yau2, Daniel D De Carvalho3.   

Abstract

In a recent issue of Cell, Bowling et al. describe a mechanism by which spliceosome-targeted therapies result in intron-containing transcripts that form double-stranded RNAs (dsRNAs), thereby activating tumor antiviral signaling (viral mimicry) and downstream adaptive immunity.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Year:  2021        PMID： 33440135     DOI： 10.1016/j.immuni.2020.12.012

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  3 in total

1.  Comprehensive analysis of spliceosome genes and their mutants across 27 cancer types in 9070 patients: clinically relevant outcomes in the context of 3P medicine.

Authors:  Zhen Ye; Aiying Bing; Shulian Zhao; Shuying Yi; Xianquan Zhan
Journal:  EPMA J       Date:  2022-05-10       Impact factor: 8.836

2.  RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis.

Authors:  Ha Zhu; Kun Chen; Yali Chen; Juan Liu; Xiaomin Zhang; Yumei Zhou; Qiuyan Liu; Bingjing Wang; Taoyong Chen; Xuetao Cao
Journal:  Signal Transduct Target Ther       Date:  2022-07-20

Review 3.  Emerging roles of spliceosome in cancer and immunity.

Authors:  Hui Yang; Bruce Beutler; Duanwu Zhang
Journal:  Protein Cell       Date:  2021-07-01       Impact factor: 15.328
  3 in total

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