PURPOSE: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). MATERIALS & METHODS: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion. RESULTS: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70). CONCLUSION: These results suggest promising protective pathway of colchicine after AMI.
PURPOSE: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). MATERIALS & METHODS: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion. RESULTS: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70). CONCLUSION: These results suggest promising protective pathway of colchicine after AMI.
Authors: Mark J Boogers; C Jan Willem Borleffs; Maureen M Henneman; Rutger J van Bommel; Jan van Ramshorst; Eric Boersma; Petra Dibbets-Schneider; Marcel P Stokkel; Ernst E van der Wall; Martin J Schalij; Jeroen J Bax Journal: J Am Coll Cardiol Date: 2010-06-15 Impact factor: 24.094
Authors: Jean-Claude Tardif; Simon Kouz; David D Waters; Olivier F Bertrand; Rafael Diaz; Aldo P Maggioni; Fausto J Pinto; Reda Ibrahim; Habib Gamra; Ghassan S Kiwan; Colin Berry; José López-Sendón; Petr Ostadal; Wolfgang Koenig; Denis Angoulvant; Jean C Grégoire; Marc-André Lavoie; Marie-Pierre Dubé; David Rhainds; Mylène Provencher; Lucie Blondeau; Andreas Orfanos; Philippe L L'Allier; Marie-Claude Guertin; François Roubille Journal: N Engl J Med Date: 2019-11-16 Impact factor: 91.245
Authors: Chia-Jen Siao; Christina U Lorentz; Pouneh Kermani; Tina Marinic; John Carter; Kelly McGrath; Victoria A Padow; Willie Mark; Domenick J Falcone; Leona Cohen-Gould; Diana C Parrish; Beth A Habecker; Anders Nykjaer; Lora H Ellenson; Lino Tessarollo; Barbara L Hempstead Journal: J Exp Med Date: 2012-10-22 Impact factor: 14.307