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Literature DB >> 33437258

Analysis of the Effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on Endothelial Function in patients with acute myocardial infarction.

Bosong Wang¹, Hong Xu², Chengqin Li³, Xiaoding Wang⁴, Weidong Sun⁵, Jinlong Li⁶.

Abstract

OBJECTIVE: This study aims to analyze the effect of lyophilized recombinant human brain natriuretic peptide on the endothelial function of patients with acute myocardial infarction.
METHODS: One hundred and thirty-six patients with acute myocardial infarction in our hospital were randomly divided into a control group and an experimental group (68 cases each). The patients in the control group were treated by conventional treatment. The patients in the experimental group were treated with lyophilized recombinant human brain natriuretic peptide besides the conventional treatment. The levels of flow-mediated dilatation (FMD), serum nitric oxide (NO), and endothelin-1 were compared between the two groups before and after treatment.
RESULTS: Before treatment, there was no significant difference between the two groups in the level of FMD (P>0.05); after treatment, the level of FMD in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05); before treatment, there was no significant difference between the two groups in the levels of serum NO and endothelin-1 (P>0.05); after treatment, the levels of serum NO and endothelin-1 in the experimental group significantly improved, which were better than those in the control group (P<0.05).
CONCLUSION: Lyophilized recombinant human brain natriuretic peptide can improve the FMD, increase the content of NO in the blood, and effectively reduce the level of endothelin-1, which is of great significance to improve the endothelial function of patients with acute myocardial infarction and is worth clinical application. Copyright: © Pakistan Journal of Medical Sciences.

Entities: Chemical

Keywords: Acute myocardial infarction; Endothelial function; Lyophilized recombinant human brain natriuretic peptide

Year: 2021 PMID： 33437258 PMCID： PMC7794129 DOI： 10.12669/pjms.37.1.2706

Source DB: PubMed Journal: Pak J Med Sci ISSN： 1681-715X Impact factor: 1.088

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1 in total

Analysis of the Effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on Endothelial Function in patients with acute myocardial infarction.

1. Combination of hypertonic saline and low-dose furosemide is an effective treatment for refractory congestive heart failure with hyponatremia.

2. Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: a randomized controlled trial.

3. Comments on the ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation.

4. Ultrasound assessment of flow-mediated dilation.

Review 5. The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives.

6. Effects of pioglitazone and metformin on vascular endothelial function in patients with type 2 diabetes treated with sulfonylureas.

7. Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction.

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1. Early Prediction of Cerebral Computed Tomography under Intelligent Segmentation Algorithm Combined with Serological Indexes for Hematoma Enlargement after Intracerebral Hemorrhage.