Literature DB >> 33436547

Targeting ubiquitin signaling for cancer immunotherapy.

Xiaofei Zhou1, Shao-Cong Sun2,3.   

Abstract

Cancer immunotherapy has become an attractive approach of cancer treatment with tremendous success in treating various advanced malignancies. The development and clinical application of immune checkpoint inhibitors represent one of the most extraordinary accomplishments in cancer immunotherapy. In addition, considerable progress is being made in understanding the mechanism of antitumor immunity and characterizing novel targets for developing additional therapeutic approaches. One active area of investigation is protein ubiquitination, a post-translational mechanism of protein modification that regulates the function of diverse immune cells in antitumor immunity. Accumulating studies suggest that E3 ubiquitin ligases and deubiquitinases form a family of potential targets to be exploited for enhancing antitumor immunity in cancer immunotherapy.

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Year:  2021        PMID： 33436547      PMCID： PMC7804490          DOI： 10.1038/s41392-020-00421-2

Source DB:  PubMed          Journal:  Signal Transduct Target Ther        ISSN： 2059-3635


  225 in total

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Authors:  Marianna Tcherpakov; Limor Broday; Agnes Delaunay; Takayuki Kadoya; Ashwani Khurana; Hediye Erdjument-Bromage; Paul Tempst; Xiao-Bo Qiu; George N DeMartino; Ze'ev Ronai
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Review 2.  Dendritic cells in cancer immunology and immunotherapy.

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Journal:  Cell       Date:  2011-08-25       Impact factor: 41.582

4.  Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity.

Authors:  Donghyun Kim; Ho Lee; Jaemoon Koh; Jae Sung Ko; Bo Ruem Yoon; Yoon Kyung Jeon; Young Min Cho; Tae Han Kim; Yun-Suhk Suh; Hyuk-Joon Lee; Han-Kwang Yang; Kyong Soo Park; Hye Young Kim; Chang Woo Lee; Won-Woo Lee; Doo Hyun Chung
Journal:  Cell Rep       Date:  2017-07-25       Impact factor: 9.423

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Authors:  Maria Letizia Giardino Torchia; Ivana Munitic; Ehydel Castro; Jasmin Herz; Dorian B McGavern; Jonathan D Ashwell
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6.  Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein.

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Journal:  Nat Med       Date:  1996-03       Impact factor: 53.440

7.  The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.

Authors:  Yu Wang; Qingguo Sun; Ning Mu; Xiaoyang Sun; Yingying Wang; Songqing Fan; Ling Su; Xiangguo Liu
Journal:  Cell Commun Signal       Date:  2020-07-14       Impact factor: 5.712

8.  USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.

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Review 9.  Therapeutic strategies for the costimulatory molecule OX40 in T-cell-mediated immunity.

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Review 10.  Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

Authors:  Si-Min Qi; Gang Cheng; Xiang-Dong Cheng; Zhiyuan Xu; Beihua Xu; Wei-Dong Zhang; Jiang-Jiang Qin
Journal:  Front Cell Dev Biol       Date:  2020-04-02
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  8 in total

1.  Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.

Authors:  Kyla D Omilusik; Marija S Nadjsombati; Tomomi M Yoshida; Laura A Shaw; John Goulding; Ananda W Goldrath
Journal:  J Immunol       Date:  2021-08-11       Impact factor: 5.426

2.  NEDD4L suppresses PD-L1 expression and enhances anti-tumor immune response in A549 cells.

Authors:  Bin Zhong; Jie Zheng; Huilan Wen; Xinhui Liao; Xingxiang Chen; Yunwei Rao; Ping Yuan
Journal:  Genes Genomics       Date:  2022-03-30       Impact factor: 2.164

3.  Protean role of epigenetic mechanisms and their impact in regulating the Tregs in TME.

Authors:  A S Smiline Girija
Journal:  Cancer Gene Ther       Date:  2021-07-28       Impact factor: 5.854

4.  UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKα2/mTOR pathway.

Authors:  Zhan Shi; Runkun Liu; Qiliang Lu; Zhi Zeng; Yang Liu; Junjun Zhao; Xin Liu; Lijie Li; Hui Huang; Yingmin Yao; Dongsheng Huang; Qiuran Xu
Journal:  Int J Med Sci       Date:  2021-10-11       Impact factor: 3.738

Review 5.  Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture.

Authors:  Mingwei Sun; Xiaofei Zhang
Journal:  Cell Biosci       Date:  2022-08-12       Impact factor: 9.584

6.  Identification of Ubiquitin-Related Gene-Pair Signatures for Predicting Tumor Microenvironment Infiltration and Drug Sensitivity of Lung Adenocarcinoma.

Authors:  Yumei Li; Lanfen An; Zhe Jia; Jingxia Li; E Zhou; Feng Wu; Zhengrong Yin; Wei Geng; Tingting Liao; Wenjing Xiao; Jingjing Deng; Wenjuan Chen; Minglei Li; Yang Jin
Journal:  Cancers (Basel)       Date:  2022-07-18       Impact factor: 6.575

Review 7.  The role of WDR76 protein in human diseases.

Authors:  Jie Yang; Fei Wang; Baoan Chen
Journal:  Bosn J Basic Med Sci       Date:  2021-10-01       Impact factor: 3.363

Review 8.  Potential of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges.

Authors:  Peng Ye; Xiaoxia Chi; Jong-Ho Cha; Shahang Luo; Guanghui Yang; Xiuwen Yan; Wen-Hao Yang
Journal:  Cells       Date:  2021-11-25       Impact factor: 6.600
  8 in total

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