Literature DB >> 33436061

Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications.

Leila Gholami1, Vajihe Taghdiri Nooshabadi2,3, Shiva Shahabi4, Marzieh Jazayeri4, Rana Tarzemany5, Zohreh Afsartala6,7, Khatereh Khorsandi8.   

Abstract

Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs' EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects.

Entities:  

Keywords:  Bone regeneration; Extracellular vesicles; Mesenchymal stem cells; Periodontal regeneration

Year:  2021        PMID： 33436061      PMCID： PMC7802187          DOI： 10.1186/s13578-020-00527-8

Source DB:  PubMed          Journal:  Cell Biosci        ISSN： 2045-3701            Impact factor:   7.133


  153 in total

1.  An autologous platelet-rich plasma stimulates periodontal ligament regeneration.

Authors:  Eduardo Anitua; María Troya; Gorka Orive
Journal:  J Periodontol       Date:  2013-01-05       Impact factor: 6.993

Review 2.  Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression.

Authors:  N J Kassebaum; E Bernabé; M Dahiya; B Bhandari; C J L Murray; W Marcenes
Journal:  J Dent Res       Date:  2014-09-26       Impact factor: 6.116

3.  A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration.

Authors:  S E Lynch; R C Williams; A M Polson; T H Howell; M S Reddy; U E Zappa; H N Antoniades
Journal:  J Clin Periodontol       Date:  1989-09       Impact factor: 8.728

4.  Treatment of periodontal furcation defects. (II). Bone regeneration in mandibular class II defects.

Authors:  B Gantes; M Martin; S Garrett; J Egelberg
Journal:  J Clin Periodontol       Date:  1988-04       Impact factor: 8.728

Review 5.  Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering.

Authors:  K Rezwan; Q Z Chen; J J Blaker; Aldo Roberto Boccaccini
Journal:  Biomaterials       Date:  2006-02-28       Impact factor: 12.479

6.  Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial.

Authors:  Myron Nevins; William V Giannobile; Michael K McGuire; Richard T Kao; James T Mellonig; James E Hinrichs; Bradley S McAllister; Kevin S Murphy; Pamela K McClain; Marc L Nevins; David W Paquette; Thomas J Han; Michael S Reddy; Philip T Lavin; Robert J Genco; Samuel E Lynch
Journal:  J Periodontol       Date:  2005-12       Impact factor: 6.993

7.  Development of the Australian Core Competencies in Musculoskeletal Basic and Clinical Science project - phase 1.

Authors:  Mellick J Chehade; Aleksander Bachorski
Journal:  Med J Aust       Date:  2008-08-04       Impact factor: 7.738

Review 8.  Tissue engineering strategies for promoting vascularized bone regeneration.

Authors:  Sarah Almubarak; Hubert Nethercott; Marie Freeberg; Caroline Beaudon; Amit Jha; Wesley Jackson; Ralph Marcucio; Theodore Miclau; Kevin Healy; Chelsea Bahney
Journal:  Bone       Date:  2015-11-19       Impact factor: 4.398

Review 9.  Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts.

Authors:  Lisa J A Heitz-Mayfield; Niklaus P Lang
Journal:  Periodontol 2000       Date:  2013-06       Impact factor: 7.589

Review 10.  Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990-2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors.

Authors:  N J Kassebaum; A G C Smith; E Bernabé; T D Fleming; A E Reynolds; T Vos; C J L Murray; W Marcenes
Journal:  J Dent Res       Date:  2017-04       Impact factor: 6.116
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  8 in total

1.  Engineered Delivery of Dental Stem-Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration.

Authors:  Jana Zarubova; Mohammad Mahdi Hasani-Sadrabadi; Erfan Dashtimoghadam; Xuexiang Zhang; Sahar Ansari; Song Li; Alireza Moshaverinia
Journal:  Adv Healthc Mater       Date:  2022-03-04       Impact factor: 11.092

2.  Clinical value of lncRNA CCAT1 in serum extracellular vesicles as a potential biomarker for gastric cancer.

Authors:  Ke Xiao; Zhaogang Dong; Ding Wang; Min Liu; Juan Ding; Wendan Chen; Ziqi Shang; Congbo Yue; Yi Zhang
Journal:  Oncol Lett       Date:  2021-04-06       Impact factor: 2.967

3.  Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway.

Authors:  Genzheng Yi; Siyuan Zhang; Yue Ma; Xueting Yang; Fangjun Huo; Yan Chen; Bo Yang; Weidong Tian
Journal:  Stem Cell Res Ther       Date:  2022-01-29       Impact factor: 6.832

Review 4.  Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration.

Authors:  Hongbing Lin; Huishan Chen; Xuetao Zhao; Zhen Chen; Peipei Zhang; Yue Tian; Yawei Wang; Tong Ding; Lijing Wang; Yuqin Shen
Journal:  J Transl Med       Date:  2021-11-04       Impact factor: 5.531

5.  An ECM-Mimetic Hydrogel to Promote the Therapeutic Efficacy of Osteoblast-Derived Extracellular Vesicles for Bone Regeneration.

Authors:  Kenny Man; Mathieu Y Brunet; Angelica S Federici; David A Hoey; Sophie C Cox
Journal:  Front Bioeng Biotechnol       Date:  2022-03-30

6.  Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair.

Authors:  Dake Hao; Lu Lu; Hengyue Song; Yixin Duan; Jianing Chen; Randy Carney; Jian Jian Li; Ping Zhou; Jan Nolta; Kit S Lam; J Kent Leach; Diana L Farmer; Alyssa Panitch; Aijun Wang
Journal:  Theranostics       Date:  2022-08-08       Impact factor: 11.600

Review 7.  Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Therapeutic Strategy for Acute Kidney Injury.

Authors:  Jia-Kun Li; Cheng Yang; Ying Su; Jing-Chao Luo; Ming-Hao Luo; Dan-Lei Huang; Guo-Wei Tu; Zhe Luo
Journal:  Front Immunol       Date:  2021-06-03       Impact factor: 8.786

8.  Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repair.

Authors:  Kenny Man; Inês A Barroso; Mathieu Y Brunet; Ben Peacock; Angelica S Federici; David A Hoey; Sophie C Cox
Journal:  Int J Mol Sci       Date:  2022-01-13       Impact factor: 5.923
  8 in total

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