Yi Zhang1, Cheng Chen1, Min Lin1, Kan Deng1, Huijuan Zhu2, Wenbin Ma1, Hui Pan2, Renzhi Wang1, Yong Yao3. 1. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. 2. Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 3. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. tigerfreeyy@126.com.
Abstract
BACKGROUND: Functional gonadotroph adenomas (FGAs) are rare adenomas that most commonly secrete FSH. However, solitary LH-secreting pituitary adenomas are unusual. CASE PRESENTATION: A 30-year-old woman with elevated LH and normal FSH presented with inability to conceive. An MRI revealed an enlarged sella turcica and an intrasellar mass. Treatment with transsphenoidal resection led to normalization of LH and estradiol, as well as successful pregnancy. And we reviewed 6 cases of LH-secreting pituitary adenomas from 1981 to 2020. CONCLUSIONS: Our case is unique because of the LH-secreting pituitary adenoma without FSH hypersecretion. This case indicates that pituitary adenoma should be considered when other diseases causing infertility have been excluded.
BACKGROUND:Functional gonadotroph adenomas (FGAs) are rare adenomas that most commonly secrete FSH. However, solitary LH-secreting pituitary adenomas are unusual. CASE PRESENTATION: A 30-year-old woman with elevated LH and normal FSH presented with inability to conceive. An MRI revealed an enlarged sella turcica and an intrasellar mass. Treatment with transsphenoidal resection led to normalization of LH and estradiol, as well as successful pregnancy. And we reviewed 6 cases of LH-secreting pituitary adenomas from 1981 to 2020. CONCLUSIONS: Our case is unique because of the LH-secreting pituitary adenoma without FSH hypersecretion. This case indicates that pituitary adenoma should be considered when other diseases causing infertility have been excluded.
Entities:
Keywords:
Case report; Infertility; Luteinizing hormone-secreting pituitary adenoma; Operation
Authors: R E Peterson; I A Kourides; M Horwith; E D Vaughan; B B Saxena; R A Fraser Journal: J Clin Endocrinol Metab Date: 1981-04 Impact factor: 5.958
Authors: A Klibanski; P J Deutsch; J L Jameson; E C Ridgway; W F Crowley; D W Hsu; J F Habener; P M Black Journal: J Clin Endocrinol Metab Date: 1987-03 Impact factor: 5.958