Jennifer Grau-Sánchez1,2,3, Emma Segura4,5, David Sanchez-Pinsach6, Preeti Raghavan7, Thomas F Münte8, Anna Marie Palumbo9,10, Alan Turry9, Esther Duarte11, Teppo Särkämö12, Jesus Cerquides6, Josep Lluis Arcos6, Antoni Rodríguez-Fornells4,5,13,14. 1. Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, 08907, Barcelona, Spain. jennifergrau@euit.fdsll.cat. 2. Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa, Autonomous University of Barcelona, C/ de la Riba, 90, 08221, Terrassa, Spain. jennifergrau@euit.fdsll.cat. 3. Institute of Neurosciences, University of Barcelona, 08035, Barcelona, Spain. jennifergrau@euit.fdsll.cat. 4. Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, 08907, Barcelona, Spain. 5. Institute of Neurosciences, University of Barcelona, 08035, Barcelona, Spain. 6. Artificial Intelligence Research Institute, Spanish National Research Council, Bellaterra, 08193, Barcelona, Spain. 7. Department of Physical Medicine and Rehabilitation, John Hopkins University, Baltimore, MD, 21287, USA. 8. Department of Neurology, University of Lübeck, 23562, Lübeck, Germany. 9. Nordoff-Robbins Center for Music Therapy, New York University, New York, 10012, USA. 10. Rehabilitation Science Program, Steinhardt School of Culture, Education and Human Development, New York University, 10003, New York, USA. 11. Department of Physical and Rehabilitation Medicine, Hospitals del Mar i l'Esperança, 08003, Barcelona, Spain. 12. Cognitive Brain Research Unit, Department of Psychology and Logopedics, University of Helsinki, 00014, Helsinki, Finland. 13. Department of Cognition, Development and Educational Psychology, University of Barcelona, 08035, Barcelona, Spain. 14. Institució Catalana de Recerca i Estudis Avançats, 08010, Barcelona, Spain.
Abstract
BACKGROUND: Residual motor deficits of the upper limb in patients with chronic stroke are common and have a negative impact on autonomy, participation and quality of life. Music-Supported Therapy (MST) is an effective intervention to enhance motor and cognitive function, emotional well-being and quality of life in chronic stroke patients. We have adapted the original MST training protocol to a home-based intervention, which incorporates increased training intensity and variability, group sessions, and optimisation of learning to promote autonomy and motivation. METHODS: A randomised controlled trial will be conducted to test the effectiveness of this enriched MST (eMST) protocol in improving motor functions, cognition, emotional well-being and quality of life of chronic stroke patients when compared to a program of home-based exercises utilizing the Graded Repetitive Arm Supplementary Program (GRASP). Sixty stroke patients will be recruited and randomly allocated to an eMST group (n = 30) or a control GRASP intervention group (n = 30). Patients will be evaluated before and after a 10-week intervention, as well as at 3-month follow-up. The primary outcome of the study is the functionality of the paretic upper limb measured with the Action Research Arm Test. Secondary outcomes include other motor and cognitive functions, emotional well-being and quality of life measures as well as self-regulation and self-efficacy outcomes. DISCUSSION: We hypothesize that patients treated with eMST will show larger improvements in their motor and cognitive functions, emotional well-being and quality of life than patients treated with a home-based GRASP intervention. TRIAL REGISTRATION: The trial has been registered at ClinicalTrials.gov and identified as NCT04507542 on 8 August 2020.
RCT Entities:
BACKGROUND: Residual motor deficits of the upper limb in patients with chronic stroke are common and have a negative impact on autonomy, participation and quality of life. Music-Supported Therapy (MST) is an effective intervention to enhance motor and cognitive function, emotional well-being and quality of life in chronic strokepatients. We have adapted the original MST training protocol to a home-based intervention, which incorporates increased training intensity and variability, group sessions, and optimisation of learning to promote autonomy and motivation. METHODS: A randomised controlled trial will be conducted to test the effectiveness of this enriched MST (eMST) protocol in improving motor functions, cognition, emotional well-being and quality of life of chronic strokepatients when compared to a program of home-based exercises utilizing the Graded Repetitive Arm Supplementary Program (GRASP). Sixty strokepatients will be recruited and randomly allocated to an eMST group (n = 30) or a control GRASP intervention group (n = 30). Patients will be evaluated before and after a 10-week intervention, as well as at 3-month follow-up. The primary outcome of the study is the functionality of the paretic upper limb measured with the Action Research Arm Test. Secondary outcomes include other motor and cognitive functions, emotional well-being and quality of life measures as well as self-regulation and self-efficacy outcomes. DISCUSSION: We hypothesize that patients treated with eMST will show larger improvements in their motor and cognitive functions, emotional well-being and quality of life than patients treated with a home-based GRASP intervention. TRIAL REGISTRATION: The trial has been registered at ClinicalTrials.gov and identified as NCT04507542 on 8 August 2020.
Entities:
Keywords:
Music therapy; Music-supported therapy; Rehabilitation; Stroke
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