Jing Wang1,2, Pei Liu1,2, Zhongzhong Liu1,2, Ye Tian3, Guilian Zhang4, Jun Guo5, Li Li6, Zhiqin Liu7, Zucheng Han8, Wenjuan Lin9, Xuemei Lin1,2, Qingli Lu1,2, Yan Liu1,2, Qiaoqiao Chang1,2, Songdi Wu10,11. 1. Department of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China. 2. Department of Neurology, the First Affiliated Hospital of Northwestern University, 710002, Xi'an, Shaanxi Province, China. 3. Department of Neurology, Third Hospital of Xi'an, the Affiliated Hospital of Northwest University, 710018, Xi'an, Shaanxi Province, China. 4. Department of Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi Province, China. 5. Department of Neurology, Tangdu Hospital, Air Force Military Medical University, 710038, Xi'an, Shaanxi Province, China. 6. Department of Neurology, Xijing Hospital, Air Force Military Medical University, 710032, Xi'an, Shaanxi Province, China. 7. Department of Neurology, Xi'an Central Hospital, Xi'an Jiaotong University School of Medicine, 710003, Xi'an, Shaanxi Province, China. 8. Encephalopathy Hospital, Shanxi Provincial Hospital of Traditional Chinese Medicine, 710077, Xi'an, Shaanxi Province, China. 9. College of Life Sciences, Northwest University, 710069, Xi'an, Shaanxi Province, China. 10. Department of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China. wusongdi@gmail.com. 11. Department of Neurology, the First Affiliated Hospital of Northwestern University, 710002, Xi'an, Shaanxi Province, China. wusongdi@gmail.com.
Abstract
BACKGROUND: Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular surface environment after dorsolateral medullary infarction. METHODS: This study will involve consecutive data from all medical records of patients within 7 days of acute dorsolateral medullary infarction onset at the Departments of Neurology from 10 collaborating stroke centers. Eligible patients will mainly be characterized based on detailed physical examinations, multimodal imaging, and corneal related examinations and patients will be followed-up for 2 years. Neurotrophic keratopathy after dorsolateral medullary infarction is the primary endpoint. The dynamic histological corneal innervation and ocular surface environment after dorsolateral medullary infarction will be observed during the follow-up period. DISCUSSION: This multicentric, prospective registry is the first to identify and characterize the dynamic changes of corneal innervation and the ocular surface environment after acute dorsolateral medullary infarction. The significance of the study is to emphasize that the curative effect is based on the doctors' identification of the disease in the earliest stage before irreversible damage occurs to the cornea. TRIAL REGISTRATION: The registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.
BACKGROUND: Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular surface environment after dorsolateral medullary infarction. METHODS: This study will involve consecutive data from all medical records of patients within 7 days of acute dorsolateral medullary infarction onset at the Departments of Neurology from 10 collaborating stroke centers. Eligible patients will mainly be characterized based on detailed physical examinations, multimodal imaging, and corneal related examinations and patients will be followed-up for 2 years. Neurotrophic keratopathy after dorsolateral medullary infarction is the primary endpoint. The dynamic histological corneal innervation and ocular surface environment after dorsolateral medullary infarction will be observed during the follow-up period. DISCUSSION: This multicentric, prospective registry is the first to identify and characterize the dynamic changes of corneal innervation and the ocular surface environment after acute dorsolateral medullary infarction. The significance of the study is to emphasize that the curative effect is based on the doctors' identification of the disease in the earliest stage before irreversible damage occurs to the cornea. TRIAL REGISTRATION: The registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.
Authors: Penny A Asbell; Maureen G Maguire; Maxwell Pistilli; Gui-shuang Ying; Loretta B Szczotka-Flynn; David R Hardten; Meng C Lin; Roni M Shtein Journal: N Engl J Med Date: 2018-04-13 Impact factor: 91.245
Authors: Sang Hee Doh; Eun Chul Kim; Se Yoon Chung; Man Soo Kim; Sung Kun Chung; Min Chul Shin; Ho Sik Hwang Journal: Ophthalmology Date: 2015-06-12 Impact factor: 12.079
Authors: Marcus Ang; Mani Baskaran; René M Werkmeister; Jacqueline Chua; Doreen Schmidl; Valentin Aranha Dos Santos; Gerhard Garhöfer; Jodhbir S Mehta; Leopold Schmetterer Journal: Prog Retin Eye Res Date: 2018-04-07 Impact factor: 21.198
Authors: C Zhao; S Lu; A Truffert; N Tajouri; K Zhao; A Mateo Montoya; A Dosso; T Landis; A B Safran Journal: Klin Monbl Augenheilkd Date: 2008-05 Impact factor: 0.700