Literature DB >> 33431045

Biological functions of m6A methyltransferases.

Jianzhong Gu1,2, Yu Zhan2, Lvjia Zhuo1,3, Qin Zhang1,3, Guohua Li1,3, Qiujie Li1,3, Shasha Qi1,3, Jinyu Zhu1,3, Qun Lv4, Yingying Shen2, Yong Guo2, Shuiping Liu5,6, Tian Xie7,8, Xinbing Sui9,10.   

Abstract

M6A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of m6A methyltransferases and explain their close connections to each other. Then, we concentrate on the extensive biological functions of m6A methyltransferases, which include cell growth, nerve development, osteogenic differentiation, metabolism, cardiovascular system homeostasis, infection and immunity, and tumour progression. We summarize the currently unresolved problems in this research field and propose expectations for m6A methyltransferases as novel targets for preventive and curative strategies for disease treatment in the future.

Entities:  

Keywords:  Growth and development; Infection and immunity; M6A methyltransferase; Metabolism; Tumour progression

Year:  2021        PMID： 33431045      PMCID： PMC7798219          DOI： 10.1186/s13578-020-00513-0

Source DB:  PubMed          Journal:  Cell Biosci        ISSN： 2045-3701            Impact factor:   7.133


  167 in total

1.  Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation.

Authors:  Tie-Gang Meng; Xukun Lu; Lei Guo; Guan-Mei Hou; Xue-Shan Ma; Qian-Nan Li; Lin Huang; Li-Hua Fan; Zheng-Hui Zhao; Xiang-Hong Ou; Ying-Chun OuYang; Heide Schatten; Lei Li; Zhen-Bo Wang; Qing-Yuan Sun
Journal:  FASEB J       Date:  2018-08-15       Impact factor: 5.191

2.  RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2.

Authors:  Ujwal Dahal; Kang Le; Mamta Gupta
Journal:  Melanoma Res       Date:  2019-08       Impact factor: 3.599

3.  N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Authors:  Yang Wang; Yue Li; Minghui Yue; Jun Wang; Sandeep Kumar; Robert J Wechsler-Reya; Zhaolei Zhang; Yuya Ogawa; Manolis Kellis; Gregg Duester; Jing Crystal Zhao
Journal:  Nat Neurosci       Date:  2018-01-15       Impact factor: 24.884

4.  Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.

Authors:  Ping Wang; Katelyn A Doxtader; Yunsun Nam
Journal:  Mol Cell       Date:  2016-06-30       Impact factor: 17.970

Review 5.  The m6A methyltransferase Ime4 and mitochondrial functions in yeast.

Authors:  Pradeep Kumar Yadav; Ram Rajasekharan
Journal:  Curr Genet       Date:  2017-10-03       Impact factor: 3.886

6.  Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.

Authors:  Philip Knuckles; Tina Lence; Irmgard U Haussmann; Dominik Jacob; Nastasja Kreim; Sarah H Carl; Irene Masiello; Tina Hares; Rodrigo Villaseñor; Daniel Hess; Miguel A Andrade-Navarro; Marco Biggiogera; Mark Helm; Matthias Soller; Marc Bühler; Jean-Yves Roignant
Journal:  Genes Dev       Date:  2018-03-13       Impact factor: 11.361

7.  METTL14 promotes the migration and invasion of breast cancer cells by modulating N6‑methyladenosine and hsa‑miR‑146a‑5p expression.

Authors:  Dandan Yi; Ru Wang; Xianbiao Shi; Lei Xu; Yiminu'er Yilihamu; Jianfeng Sang
Journal:  Oncol Rep       Date:  2020-02-24       Impact factor: 3.906

8.  METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation.

Authors:  Zeyu Zhang; Meng Wang; Dongfang Xie; Zenghui Huang; Lisha Zhang; Ying Yang; Dongxue Ma; Wenguang Li; Qi Zhou; Yun-Gui Yang; Xiu-Jie Wang
Journal:  Cell Res       Date:  2018-10-08       Impact factor: 25.617

9.  m6A mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes.

Authors:  Dario F De Jesus; Zijie Zhang; Sevim Kahraman; Natalie K Brown; Mengjie Chen; Jiang Hu; Manoj K Gupta; Chuan He; Rohit N Kulkarni
Journal:  Nat Metab       Date:  2019-07-29

10.  METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.

Authors:  Yiwen Zhang; Xiaofei Gu; Di Li; Luhui Cai; Qiong Xu
Journal:  Int J Mol Sci       Date:  2019-12-27       Impact factor: 5.923
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  9 in total

1.  Identification of an N6-methyladenosine (m6A)-related signature associated with clinical prognosis, immune response, and chemotherapy in primary glioblastomas.

Authors:  Zhiqiang Cai; Jianbo Zhang; Ziying Liu; Jiahao Su; Jing Xu; Zhenjun Li; Hongliang Meng; Heng Zhang; Minjie Huang; Donghai Zhao; Chuanzhi Duan; Xuying He
Journal:  Ann Transl Med       Date:  2021-08

2.  Eltrombopag as an Allosteric Inhibitor of the METTL3-14 Complex Affecting the m6A Methylation of RNA in Acute Myeloid Leukemia Cells.

Authors:  Je-Heon Lee; Namjeong Choi; Subin Kim; Mi Sun Jin; Haihong Shen; Yong-Chul Kim
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-01

Review 3.  The role of N6-methyladenosine (m6A) in eye diseases.

Authors:  Jing-Fan Gao; Lu Zhang
Journal:  Mol Biol Rep       Date:  2021-07-31       Impact factor: 2.316

Review 4.  Current Advances in N6-Methyladenosine Methylation Modification During Bladder Cancer.

Authors:  Qiang Liu
Journal:  Front Genet       Date:  2022-01-11       Impact factor: 4.599

5.  m6A Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Pancreatic Cancer.

Authors:  Mengyu Sun; Meng Xie; Tongyue Zhang; Yijun Wang; Wenjie Huang; Limin Xia
Journal:  Front Immunol       Date:  2021-09-20       Impact factor: 7.561

6.  Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury.

Authors:  Boyang Liu; Shengxiang Ao; Fang Tan; Wei Ma; Haoru Liu; Huaping Liang; Xia Yang; Xinjin Chi
Journal:  Ann Transl Med       Date:  2022-07

Review 7.  Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy.

Authors:  Su Zhang; Yang Meng; Lian Zhou; Lei Qiu; Heping Wang; Dan Su; Bo Zhang; Kui-Ming Chan; Junhong Han
Journal:  MedComm (2020)       Date:  2022-09-15

8.  YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy.

Authors:  Hongfei Xu; Zhen Wang; Miao Chen; Wenting Zhao; Tingting Tao; Liang Ma; Yiming Ni; Weidong Li
Journal:  Cell Biosci       Date:  2021-07-15       Impact factor: 7.133

Review 9.  N6-Methyladenosine RNA Modification in the Tumor Immune Microenvironment: Novel Implications for Immunotherapy.

Authors:  Liting Guo; Hui Yang; Chenfei Zhou; Yan Shi; Lei Huang; Jun Zhang
Journal:  Front Immunol       Date:  2021-12-09       Impact factor: 7.561
  9 in total

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