| Literature DB >> 33430758 |
Parmissa Randhawa1, Aeli P Olson2, Shaohuang Chen1, Kaley Lexi Gower-Fry1, Cornelia Hoehr3, Jonathan W Engle2, Caterina F Ramogida1, Valery Radchenko3.
Abstract
Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Targeted radionuclide therapy (TRT); antimony-119 (119Sb); auger electrons; coordination; dosimetry.; imaging; mercury-197 (197Hg); production; radiochemicalzzm321990separation
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Year: 2021 PMID： 33430758 PMCID： PMC8521447 DOI： 10.2174/1874471014999210111201630
Source DB: PubMed Journal: Curr Radiopharm ISSN： 1874-4710