Literature DB >> 33430260

Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection.

Giuseppe Cappellano1,2, Davide Raineri1,2, Roberta Rolla1,3, Mara Giordano1,3, Chiara Puricelli3, Beatrice Vilardo1,2, Marcello Manfredi2,4, Vincenzo Cantaluppi2,4,5, Pier Paolo Sainaghi2,4,6, Luigi Castello4,7, Nello De Vita4, Lorenza Scotti4, Rosanna Vaschetto4, Umberto Dianzani1,3, Annalisa Chiocchetti1,2.   

Abstract

Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the diagnostic performance of circulating platelets (PLT)-derived extracellular vesicles (EVs) as biomarkers for Sars-Cov-2 infection, by setting a rapid and reliable test on unmanipulated blood samples. PLT-EVs were quantified by flow cytometry on two independent cohorts of Sars-CoV-2+ (n = 69), Sars-Cov-2- (n = 62) hospitalized patients, and healthy controls. Diagnostic performance of PLT-EVs was evaluated by receiver operating characteristic (ROC) curve. PLT-EVs count were higher in Sars-Cov-2+ compared to Sars-Cov-2- patients or HC. ROC analysis of the combined cohorts showed an AUC = 0.79 and an optimal cut-off value of 1472 EVs/μL, with 75% sensitivity and 74% specificity. These data suggest that PLT-EVs might be an interesting biomarker deserving further investigations to test their predictive power.

Entities:  

Keywords:  COVID-19; Sars-Cov-2; circulating biomarker; extracellular vesicles; platelets

Mesh：

Substances：

Year:  2021        PMID： 33430260      PMCID： PMC7825711          DOI： 10.3390/cells10010085

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  25 in total

1.  Analytical Considerations in Nanoscale Flow Cytometry of Extracellular Vesicles to Achieve Data Linearity.

Authors:  Janice Gomes; Fabrice Lucien; Tyler T Cooper; Yohan Kim; Karla C Williams; XinYang Liao; Lauren Kaufman; Francois Lagugné-Labarthet; Oliver Kenyon; Justin Boysen; Neil E Kay; Christopher W McIntyre; Hon S Leong
Journal:  Thromb Haemost       Date:  2018-08-15       Impact factor: 5.249

2.  Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration.

Authors:  N Arraud; R Linares; S Tan; C Gounou; J-M Pasquet; S Mornet; A R Brisson
Journal:  J Thromb Haemost       Date:  2014-05       Impact factor: 5.824

Review 3.  Extracellular Vesicles: Unique Intercellular Delivery Vehicles.

Authors:  Sybren L N Maas; Xandra O Breakefield; Alissa M Weaver
Journal:  Trends Cell Biol       Date:  2016-12-13       Impact factor: 20.808

4.  Levels of activated platelet-derived microvesicles in patients with soft tissue sarcoma correlate with an increased risk of venous thromboembolism.

Authors:  A Fricke; P V Ullrich; A F V Cimniak; C Becherer; M Follo; J Heinz; J Scholber; G W Herget; O Hauschild; U A Wittel; G B Stark; H Bannasch; D Braig; S U Eisenhardt
Journal:  BMC Cancer       Date:  2017-08-07       Impact factor: 4.430

5.  Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients.

Authors:  Damiana Pieragostino; Ilaria Cicalini; Paola Lanuti; Eva Ercolino; Maria di Ioia; Mirco Zucchelli; Romina Zappacosta; Sebastiano Miscia; Marco Marchisio; Paolo Sacchetta; Marco Onofrj; Piero Del Boccio
Journal:  Sci Rep       Date:  2018-02-15       Impact factor: 4.379

6.  Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:  Clotilde Théry; Kenneth W Witwer; Elena Aikawa; Maria Jose Alcaraz; Johnathon D Anderson; Ramaroson Andriantsitohaina; Anna Antoniou; Tanina Arab; Fabienne Archer; Georgia K Atkin-Smith; D Craig Ayre; Jean-Marie Bach; Daniel Bachurski; Hossein Baharvand; Leonora Balaj; Shawn Baldacchino; Natalie N Bauer; Amy A Baxter; Mary Bebawy; Carla Beckham; Apolonija Bedina Zavec; Abderrahim Benmoussa; Anna C Berardi; Paolo Bergese; Ewa Bielska; Cherie Blenkiron; Sylwia Bobis-Wozowicz; Eric Boilard; Wilfrid Boireau; Antonella Bongiovanni; Francesc E Borràs; Steffi Bosch; Chantal M Boulanger; Xandra Breakefield; Andrew M Breglio; Meadhbh Á Brennan; David R Brigstock; Alain Brisson; Marike Ld Broekman; Jacqueline F Bromberg; Paulina Bryl-Górecka; Shilpa Buch; Amy H Buck; Dylan Burger; Sara Busatto; Dominik Buschmann; Benedetta Bussolati; Edit I Buzás; James Bryan Byrd; Giovanni Camussi; David Rf Carter; Sarah Caruso; Lawrence W Chamley; Yu-Ting Chang; Chihchen Chen; Shuai Chen; Lesley Cheng; Andrew R Chin; Aled Clayton; Stefano P Clerici; Alex Cocks; Emanuele Cocucci; Robert J Coffey; Anabela Cordeiro-da-Silva; Yvonne Couch; Frank Aw Coumans; Beth Coyle; Rossella Crescitelli; Miria Ferreira Criado; Crislyn D'Souza-Schorey; Saumya Das; Amrita Datta Chaudhuri; Paola de Candia; Eliezer F De Santana; Olivier De Wever; Hernando A Del Portillo; Tanguy Demaret; Sarah Deville; Andrew Devitt; Bert Dhondt; Dolores Di Vizio; Lothar C Dieterich; Vincenza Dolo; Ana Paula Dominguez Rubio; Massimo Dominici; Mauricio R Dourado; Tom Ap Driedonks; Filipe V Duarte; Heather M Duncan; Ramon M Eichenberger; Karin Ekström; Samir El Andaloussi; Celine Elie-Caille; Uta Erdbrügger; Juan M Falcón-Pérez; Farah Fatima; Jason E Fish; Miguel Flores-Bellver; András Försönits; Annie Frelet-Barrand; Fabia Fricke; Gregor Fuhrmann; Susanne Gabrielsson; Ana Gámez-Valero; Chris Gardiner; Kathrin Gärtner; Raphael Gaudin; Yong Song Gho; Bernd Giebel; Caroline Gilbert; Mario Gimona; Ilaria Giusti; Deborah Ci Goberdhan; André Görgens; Sharon M Gorski; David W Greening; Julia Christina Gross; Alice Gualerzi; Gopal N Gupta; Dakota Gustafson; Aase Handberg; Reka A Haraszti; Paul Harrison; Hargita Hegyesi; An Hendrix; Andrew F Hill; Fred H Hochberg; Karl F Hoffmann; Beth Holder; Harry Holthofer; Baharak Hosseinkhani; Guoku Hu; Yiyao Huang; Veronica Huber; Stuart Hunt; Ahmed Gamal-Eldin Ibrahim; Tsuneya Ikezu; Jameel M Inal; Mustafa Isin; Alena Ivanova; Hannah K Jackson; Soren Jacobsen; Steven M Jay; Muthuvel Jayachandran; Guido Jenster; Lanzhou Jiang; Suzanne M Johnson; Jennifer C Jones; Ambrose Jong; Tijana Jovanovic-Talisman; Stephanie Jung; Raghu Kalluri; Shin-Ichi Kano; Sukhbir Kaur; Yumi Kawamura; Evan T Keller; Delaram Khamari; Elena Khomyakova; Anastasia Khvorova; Peter Kierulf; Kwang Pyo Kim; Thomas Kislinger; Mikael Klingeborn; David J Klinke; Miroslaw Kornek; Maja M Kosanović; Árpád Ferenc Kovács; Eva-Maria Krämer-Albers; Susanne Krasemann; Mirja Krause; Igor V Kurochkin; Gina D Kusuma; Sören Kuypers; Saara Laitinen; Scott M Langevin; Lucia R Languino; Joanne Lannigan; Cecilia Lässer; Louise C Laurent; Gregory Lavieu; Elisa Lázaro-Ibáñez; Soazig Le Lay; Myung-Shin Lee; Yi Xin Fiona Lee; Debora S Lemos; Metka Lenassi; Aleksandra Leszczynska; Isaac Ts Li; Ke Liao; Sten F Libregts; Erzsebet Ligeti; Rebecca Lim; Sai Kiang Lim; Aija Linē; Karen Linnemannstöns; Alicia Llorente; Catherine A Lombard; Magdalena J Lorenowicz; Ákos M Lörincz; Jan Lötvall; Jason Lovett; Michelle C Lowry; Xavier Loyer; Quan Lu; Barbara Lukomska; Taral R Lunavat; Sybren Ln Maas; Harmeet Malhi; Antonio Marcilla; Jacopo Mariani; Javier Mariscal; Elena S Martens-Uzunova; Lorena Martin-Jaular; M Carmen Martinez; Vilma Regina Martins; Mathilde Mathieu; Suresh Mathivanan; Marco Maugeri; Lynda K McGinnis; Mark J McVey; David G Meckes; Katie L Meehan; Inge Mertens; Valentina R Minciacchi; Andreas Möller; Malene Møller Jørgensen; Aizea Morales-Kastresana; Jess Morhayim; François Mullier; Maurizio Muraca; Luca Musante; Veronika Mussack; Dillon C Muth; Kathryn H Myburgh; Tanbir Najrana; Muhammad Nawaz; Irina Nazarenko; Peter Nejsum; Christian Neri; Tommaso Neri; Rienk Nieuwland; Leonardo Nimrichter; John P Nolan; Esther Nm Nolte-'t Hoen; Nicole Noren Hooten; Lorraine O'Driscoll; Tina O'Grady; Ana O'Loghlen; Takahiro Ochiya; Martin Olivier; Alberto Ortiz; Luis A Ortiz; Xabier Osteikoetxea; Ole Østergaard; Matias Ostrowski; Jaesung Park; D Michiel Pegtel; Hector Peinado; Francesca Perut; Michael W Pfaffl; Donald G Phinney; Bartijn Ch Pieters; Ryan C Pink; David S Pisetsky; Elke Pogge von Strandmann; Iva Polakovicova; Ivan Kh Poon; Bonita H Powell; Ilaria Prada; Lynn Pulliam; Peter Quesenberry; Annalisa Radeghieri; Robert L Raffai; Stefania Raimondo; Janusz Rak; Marcel I Ramirez; Graça Raposo; Morsi S Rayyan; Neta Regev-Rudzki; Franz L Ricklefs; Paul D Robbins; David D Roberts; Silvia C Rodrigues; Eva Rohde; Sophie Rome; Kasper Ma Rouschop; Aurelia Rughetti; Ashley E Russell; Paula Saá; Susmita Sahoo; Edison Salas-Huenuleo; Catherine Sánchez; Julie A Saugstad; Meike J Saul; Raymond M Schiffelers; Raphael Schneider; Tine Hiorth Schøyen; Aaron Scott; Eriomina Shahaj; Shivani Sharma; Olga Shatnyeva; Faezeh Shekari; Ganesh Vilas Shelke; Ashok K Shetty; Kiyotaka Shiba; Pia R-M Siljander; Andreia M Silva; Agata Skowronek; Orman L Snyder; Rodrigo Pedro Soares; Barbara W Sódar; Carolina Soekmadji; Javier Sotillo; Philip D Stahl; Willem Stoorvogel; Shannon L Stott; Erwin F Strasser; Simon Swift; Hidetoshi Tahara; Muneesh Tewari; Kate Timms; Swasti Tiwari; Rochelle Tixeira; Mercedes Tkach; Wei Seong Toh; Richard Tomasini; Ana Claudia Torrecilhas; Juan Pablo Tosar; Vasilis Toxavidis; Lorena Urbanelli; Pieter Vader; Bas Wm van Balkom; Susanne G van der Grein; Jan Van Deun; Martijn Jc van Herwijnen; Kendall Van Keuren-Jensen; Guillaume van Niel; Martin E van Royen; Andre J van Wijnen; M Helena Vasconcelos; Ivan J Vechetti; Tiago D Veit; Laura J Vella; Émilie Velot; Frederik J Verweij; Beate Vestad; Jose L Viñas; Tamás Visnovitz; Krisztina V Vukman; Jessica Wahlgren; Dionysios C Watson; Marca Hm Wauben; Alissa Weaver; Jason P Webber; Viktoria Weber; Ann M Wehman; Daniel J Weiss; Joshua A Welsh; Sebastian Wendt; Asa M Wheelock; Zoltán Wiener; Leonie Witte; Joy Wolfram; Angeliki Xagorari; Patricia Xander; Jing Xu; Xiaomei Yan; María Yáñez-Mó; Hang Yin; Yuana Yuana; Valentina Zappulli; Jana Zarubova; Vytautas Žėkas; Jian-Ye Zhang; Zezhou Zhao; Lei Zheng; Alexander R Zheutlin; Antje M Zickler; Pascale Zimmermann; Angela M Zivkovic; Davide Zocco; Ewa K Zuba-Surma
Journal:  J Extracell Vesicles       Date:  2018-11-23

7.  Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2.

Authors:  Pei-Shan Sung; Tur-Fu Huang; Shie-Liang Hsieh
Journal:  Nat Commun       Date:  2019-06-03       Impact factor: 14.919

8.  Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia.

Authors:  Songping Cui; Shuo Chen; Xiunan Li; Shi Liu; Feng Wang
Journal:  J Thromb Haemost       Date:  2020-05-06       Impact factor: 5.824

Review 9.  Extracellular vesicles: exosomes, microvesicles, and friends.

Authors:  Graça Raposo; Willem Stoorvogel
Journal:  J Cell Biol       Date:  2013-02-18       Impact factor: 10.539

10.  Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19.

Authors:  Younes Zaid; Florian Puhm; Isabelle Allaeys; Abdallah Naya; Mounia Oudghiri; Loubna Khalki; Youness Limami; Nabil Zaid; Khalid Sadki; Rafiqua Ben El Haj; Wissal Mahir; Lamiae Belayachi; Bouchra Belefquih; Amina Benouda; Amine Cheikh; Marc-André Langlois; Yahia Cherrah; Louis Flamand; Fadila Guessous; Eric Boilard
Journal:  Circ Res       Date:  2020-09-17       Impact factor: 17.367
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  34 in total

1.  Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients.

Authors:  Davide Raineri; Chiara Venegoni; Maria Grazia Calella; Rosanna Vaschetto; Lorenza Scotti; Elena Canciani; Marcello Manfredi; Francesco Gavelli; Luigi Castello; Annalisa Chiocchetti; Giuseppe Cappellano
Journal:  Dis Markers       Date:  2022-07-07       Impact factor: 3.464

Review 2.  Activated Platelets and Platelet-Derived Extracellular Vesicles Mediate COVID-19-Associated Immunothrombosis.

Authors:  Marie Ebeyer-Masotta; Tanja Eichhorn; René Weiss; Lucia Lauková; Viktoria Weber
Journal:  Front Cell Dev Biol       Date:  2022-07-06

3.  CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation.

Authors:  Pei-Shan Sung; Shao-Ping Yang; Yu-Chun Peng; Cheng-Pu Sun; Mi-Hwa Tao; Shie-Liang Hsieh
Journal:  J Biomed Sci       Date:  2022-07-11       Impact factor: 12.771

Review 4.  Systematic review on role of structure based drug design (SBDD) in the identification of anti-viral leads against SARS-Cov-2.

Authors:  Nilesh Gajanan Bajad; Swetha Rayala; Gopichand Gutti; Anjali Sharma; Meenakshi Singh; Ashok Kumar; Sushil Kumar Singh
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-05-14

Review 5.  Platelets: "multiple choice" effectors in the immune response and their implication in COVID-19 thromboinflammatory process.

Authors:  Roberta Rolla; Chiara Puricelli; Alessandra Bertoni; Elena Boggio; Casimiro Luca Gigliotti; Annalisa Chiocchetti; Giuseppe Cappellano; Umberto Dianzani
Journal:  Int J Lab Hematol       Date:  2021-03-22       Impact factor: 3.450

6.  High levels of circulating osteopontin in inflammatory lung disease regardless of Sars-CoV-2 infection.

Authors:  Giuseppe Cappellano; Hugo Abreu; Davide Raineri; Lorenza Scotti; Luigi Castello; Rosanna Vaschetto; Annalisa Chiocchetti
Journal:  EMBO Mol Med       Date:  2021-03-31       Impact factor: 12.137

Review 7.  C-type lectins and extracellular vesicles in virus-induced NETosis.

Authors:  Pei-Shan Sung; Shie-Liang Hsieh
Journal:  J Biomed Sci       Date:  2021-06-11       Impact factor: 8.410

Review 8.  Extracellular Vesicles: Versatile Nanomediators, Potential Biomarkers and Therapeutic Agents in Atherosclerosis and COVID-19-Related Thrombosis.

Authors:  Adriana Georgescu; Maya Simionescu
Journal:  Int J Mol Sci       Date:  2021-05-31       Impact factor: 5.923

Review 9.  Targeting SARS-CoV-2-Platelet Interactions in COVID-19 and Vaccine-Related Thrombosis.

Authors:  Dermot Cox
Journal:  Front Pharmacol       Date:  2021-07-05       Impact factor: 5.810

Review 10.  Nano-Microparticle Platforms in Developing Next-Generation Vaccines.

Authors:  Giuseppe Cappellano; Hugo Abreu; Chiara Casale; Umberto Dianzani; Annalisa Chiocchetti
Journal:  Vaccines (Basel)       Date:  2021-06-05
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