Wiebke Reichstein1, Levke Sommer2, Salih Veziroglu1, Selin Sayin3, Stefan Schröder1, Yogendra Kumar Mishra4, Eyüp İlker Saygili5, Fatih Karayürek6, Yahya Açil2, Jörg Wiltfang2, Aydin Gülses2, Franz Faupel1, Oral Cenk Aktas1. 1. Chair for Multicomponent Materials, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143 Kiel, Germany. 2. Department of Oral and Maxillofacial Surgery, Campus Kiel, University Hospital of Schleswig-Holstein, Arnold-Heller-Straße 3, 24105 Kiel, Germany. 3. Marine Science and Technology Faculty, Iskenderun Technical University, 31200 Iskenderun/Hatay, Turkey. 4. Mads Clausen Institute, NanoSYD, University of Southern Denmark, Alsion 2, 6400 Sønderborg, Denmark. 5. Department of Medical Biochemistry, SANKO University, Şehitkamil, 27090 Gaziantep, Turkey. 6. Department of Periodontology, Cankiri Karatekin University, 18100 Cankiri, Turkey.
Abstract
The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP-PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.
The current study aimed to describe the fabrication pan class="Gene">of a composite patch by incorporating marine algae powders (MAPs) intopoly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP-PLA composite patch showed superior cell interaction ofhuman osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.
Authors: Se Woong Park; Donghyun Lee; Hak Rae Lee; Ho-Jin Moon; Bo Ra Lee; Wan-Kyu Ko; Su-Jin Song; Sang Jin Lee; Kwanwoo Shin; Wonhyeong Jang; Jin-Kyu Yi; Sung Gap Im; Il Keun Kwon Journal: J Colloid Interface Sci Date: 2014-10-19 Impact factor: 8.128
Authors: Virginia Llopis-Hernández; Patricia Rico; José Ballester-Beltrán; David Moratal; Manuel Salmerón-Sánchez Journal: PLoS One Date: 2011-05-09 Impact factor: 3.240
Authors: Antonia Terriza; José I Vilches-Pérez; Juan L González-Caballero; Emilio de la Orden; Francisco Yubero; Angel Barranco; Agustín R Gonzalez-Elipe; José Vilches; Mercedes Salido Journal: Materials (Basel) Date: 2014-03-04 Impact factor: 3.623