Literature DB >> 33428509

The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey.

Amita Sehgal1.   

Abstract

The circadian field has come a long way since I started as a postdoctoral fellow ~30 years ago. At the time, the only known animal clock gene was period, so I had the privilege of witnessing, and participating in, the molecular revolution that took us from the discovery of the circadian clock mechanism to the identification of pathways that link clocks to behavior and physiology. This lecture highlights my role and perspective in these developments, and also demonstrates how the successful use of Drosophila for studies of circadian rhythms inspired us to develop a fly model for sleep. I also touch upon my experiences as a non-white immigrant woman navigating my way through the US science and education system, and hope my story will be of interest to some.

Entities:  

Keywords:  Drosophila; anti-microbial peptide; light resetting; period; sleep; timeless

Mesh:

Year:  2021        PMID: 33428509      PMCID: PMC8815313          DOI: 10.1177/0748730420982398

Source DB:  PubMed          Journal:  J Biol Rhythms        ISSN: 0748-7304            Impact factor:   3.182


  52 in total

1.  Identification of a circadian output circuit for rest:activity rhythms in Drosophila.

Authors:  Daniel J Cavanaugh; Jill D Geratowski; Julian R A Wooltorton; Jennifer M Spaethling; Clare E Hector; Xiangzhong Zheng; Erik C Johnson; James H Eberwine; Amita Sehgal
Journal:  Cell       Date:  2014-04-24       Impact factor: 41.582

2.  Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster.

Authors:  Edith M Myers; Jiujiu Yu; Amita Sehgal
Journal:  Curr Biol       Date:  2003-03-18       Impact factor: 10.834

3.  Lethargus is a Caenorhabditis elegans sleep-like state.

Authors:  David M Raizen; John E Zimmerman; Matthew H Maycock; Uyen D Ta; Young-jai You; Meera V Sundaram; Allan I Pack
Journal:  Nature       Date:  2008-01-09       Impact factor: 49.962

4.  Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.

Authors:  N Gekakis; L Saez; A M Delahaye-Brown; M P Myers; A Sehgal; M W Young; C J Weitz
Journal:  Science       Date:  1995-11-03       Impact factor: 47.728

5.  A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.

Authors:  Anna N King; Annika F Barber; Amelia E Smith; Austin P Dreyer; Divya Sitaraman; Michael N Nitabach; Daniel J Cavanaugh; Amita Sehgal
Journal:  Curr Biol       Date:  2017-06-29       Impact factor: 10.834

6.  Forward-genetics analysis of sleep in randomly mutagenized mice.

Authors:  Hiromasa Funato; Chika Miyoshi; Tomoyuki Fujiyama; Takeshi Kanda; Makito Sato; Zhiqiang Wang; Jing Ma; Shin Nakane; Jun Tomita; Aya Ikkyu; Miyo Kakizaki; Noriko Hotta-Hirashima; Satomi Kanno; Haruna Komiya; Fuyuki Asano; Takato Honda; Staci J Kim; Kanako Harano; Hiroki Muramoto; Toshiya Yonezawa; Seiya Mizuno; Shinichi Miyazaki; Linzi Connor; Vivek Kumar; Ikuo Miura; Tomohiro Suzuki; Atsushi Watanabe; Manabu Abe; Fumihiro Sugiyama; Satoru Takahashi; Kenji Sakimura; Yu Hayashi; Qinghua Liu; Kazuhiko Kume; Shigeharu Wakana; Joseph S Takahashi; Masashi Yanagisawa
Journal:  Nature       Date:  2016-11-02       Impact factor: 49.962

7.  Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila.

Authors:  Cory Pfeiffenberger; Ravi Allada
Journal:  PLoS Genet       Date:  2012-10-04       Impact factor: 5.917

8.  Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells.

Authors:  Annika F Barber; Renske Erion; Todd C Holmes; Amita Sehgal
Journal:  Genes Dev       Date:  2016-12-15       Impact factor: 11.361

9.  Endocytosis at the Drosophila blood-brain barrier as a function for sleep.

Authors:  Gregory Artiushin; Shirley L Zhang; Hervé Tricoire; Amita Sehgal
Journal:  Elife       Date:  2018-11-26       Impact factor: 8.140

10.  G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.

Authors:  Yool Lee; Nicholas F Lahens; Shirley Zhang; Joseph Bedont; Jeffrey M Field; Amita Sehgal
Journal:  PLoS Biol       Date:  2019-04-30       Impact factor: 8.029

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