PRECIS: Steroid response after cataract surgery was more frequent in glaucoma patients than non-glaucoma patients. Longer axial length and more preoperative medications were risk factors for steroid response in glaucoma patients. PURPOSE: To evaluate incidence and risk factors for topical steroid response after uneventful cataract surgery in patients with and without glaucoma. SETTING: Academic glaucoma clinics. DESIGN: Retrospective review. PARTICIPANTS: Consecutive patients with and without glaucoma and no prior incisional glaucoma surgery undergoing cataract surgery between March 2007 and September 2016. All patients routinely received topical prednisolone acetate 1% postoperatively. METHODS: Pertinent clinical information was recorded. Steroid response was defined as IOP >50% above the baseline IOP measurement, occurring at or after the second postoperative week. RESULTS: We included 472 eyes of 472 non-glaucoma patients and 191 eyes of 191 glaucoma patients. Ten (2.1%) non-glaucoma eyes and 16 (8.4%) glaucoma eyes were diagnosed as steroid responders (relative risk= 3.72, 95% confidence interval 1.71-8.07, P<0.001). Logistic regression showed that for non-glaucoma, longer axial length (AL) and younger age were associated with a higher incidence of steroid response (P≤0.003), while for glaucoma patients, longer AL and more preoperative medications were associated with steroid response (P≤0.030). An AL ≥26▒mm was associated with steroid response for both groups (P≤0.024). CONCLUSION: Although glaucoma patients were 3.72 times more likely to have steroid response after uneventful cataract surgery, the incidence of steroid response with prednisolone acetate 1% was relatively low after phacoemulsification in both non-glaucoma and glaucoma eyes. Steroid response was associated with longer AL in both groups and with more preoperative medications in glaucoma patients.
PRECIS: Steroid response after cataract surgery was more frequent in glaucomapatients than non-glaucomapatients. Longer axial length and more preoperative medications were risk factors for steroid response in glaucomapatients. PURPOSE: To evaluate incidence and risk factors for topicalsteroid response after uneventful cataract surgery in patients with and without glaucoma. SETTING: Academic glaucoma clinics. DESIGN: Retrospective review. PARTICIPANTS: Consecutive patients with and without glaucoma and no prior incisionalglaucoma surgery undergoing cataract surgery between March 2007 and September 2016. All patients routinely received topicalprednisolone acetate 1% postoperatively. METHODS: Pertinent clinical information was recorded. Steroid response was defined as IOP >50% above the baseline IOP measurement, occurring at or after the second postoperative week. RESULTS: We included 472 eyes of 472 non-glaucomapatients and 191 eyes of 191 glaucomapatients. Ten (2.1%) non-glaucoma eyes and 16 (8.4%) glaucoma eyes were diagnosed as steroid responders (relative risk= 3.72, 95% confidence interval 1.71-8.07, P<0.001). Logistic regression showed that for non-glaucoma, longer axial length (AL) and younger age were associated with a higher incidence of steroid response (P≤0.003), while for glaucomapatients, longer AL and more preoperative medications were associated with steroid response (P≤0.030). An AL ≥26▒mm was associated with steroid response for both groups (P≤0.024). CONCLUSION:Although glaucomapatients were 3.72 times more likely to have steroid response after uneventful cataract surgery, the incidence of steroid response with prednisolone acetate 1% was relatively low after phacoemulsification in both non-glaucoma and glaucoma eyes. Steroid response was associated with longer AL in both groups and with more preoperative medications in glaucomapatients.