Shangzhu Zhang1, Yanhong Wang2, Linyi Peng1, Jinmei Su1, Xiaofeng Zeng1, Mengtao Li1, Zhenbiao Wu3, Jian Xu4, Min Yang5, Lijun Wu6, Cheng Zhao7, Xinwang Duan8, Qin Li9, Jing Zhu10, Wenqiang Fan11. 1. Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. 2. Department of Epidemiology and Bio-Statistics (YW), Peking Union Medical College, Institute of Basic Medical Sciences, China Academy of Medical Sciences, Beijing, China. 3. Department of Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Xi'an, China. 4. Department of Rheumatology, Kunming Medical University First Affiliated Hospital, Kunming, China. 5. Department of Rheumatology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, China. 6. Department of Rheumatology, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China. 7. Department of Rheumatology, Guangxi Medical University First Affiliated Hospital, Nanning, China. 8. Department of Rheumatology, Nanchang University Second Affiliated Hospital, Nanchang, China. 9. Department of Rheumatology, First People's Hospital of Yunnan, Kunming, China. 10. Department of Rheumatology, Sichuan Provincial People's Hospital, Chengdu, China. 11. Department of Rheumatology, Xinxiang Central Hospital, Xinxiang, China.
Abstract
Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China. Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence. Results: We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender (p < 0.001), younger age (p < 0.001), a disease duration of more than 3 years (p < 0.001), a family history of SpA (p < 0.001), uveitis (p < 0.001), ASDAS-CRP (p < 0.001), and biologic treatment (p < 0.001) were the main variables that were independently related to HLA-B27 presence, whereas a diagnosis delay time >36 months (p < 0.001) and psoriasis (p < 0.001) were independently related to HLA-B27 absence. Conclusion: In Chinese axial SpA patients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis.
Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China. Methods: An observational, cross-sectional, and analytic study of axSpApatients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence. Results: We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender (p < 0.001), younger age (p < 0.001), a disease duration of more than 3 years (p < 0.001), a family history of SpA (p < 0.001), uveitis (p < 0.001), ASDAS-CRP (p < 0.001), and biologic treatment (p < 0.001) were the main variables that were independently related to HLA-B27 presence, whereas a diagnosis delay time >36 months (p < 0.001) and psoriasis (p < 0.001) were independently related to HLA-B27 absence. Conclusion: In Chinese axial SpApatients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis.
Authors: Charles A Hay; Jon Packham; Sarah Ryan; Christian D Mallen; Alexandros Chatzixenitidis; James A Prior Journal: Clin Rheumatol Date: 2022-02-19 Impact factor: 3.650