Yongping Cai1,2, Yong Chen3,1, Xingwang Wu4, Yu Yin1,2, Liyu Cao1,2, Xiuli Liu5. 1. Department of Pathology, Anhui Medical University Hefei, Anhui Province, China. 2. Department of Pathology, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui Province, China. 3. Department of Pathology, Anhui Province Maternal and Child Health Hospital Hefei, Anhui Province, China. 4. Department of Imaging, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui Province, China. 5. Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida Gainesville, FL, USA.
Abstract
BACKGROUND: Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas is a very rare variant of pancreatic malignant neoplasm. It is regarded as a highly aggressive tumor with a worse prognosis than conventional pancreatic ductal adenocarcinoma. CASE PRESENTATION: A 54-year-old male patient presented with 3-month recurrent epigastric distress. Computed tomography of the abdomen showed a large cystic mass in the distal pancreas. On macroscopic examination, the lesion had numerous multiloculated cystic cavities. Microscopically, the tumor predominantly comprised a considerable number of evenly distributed non-neoplastic osteoclast-like giant cells and a few neoplastic pleomorphic cells. Although extensive histologic sampling was conducted, a classic ductal adenocarcinoma component was not identified. The patient received no further treatment after his surgery and has been doing well with no evidence of recurrence or metastasis for >7 years. CONCLUSIONS: Our results suggest that pure UCOGC has a significantly better prognosis and supports that pure UCOGC may represent a biologically distinct variant of pancreatic carcinoma and it should be separated from other undifferentiated pancreatic carcinomas. IJCEP
BACKGROUND:Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas is a very rare variant of pancreatic malignant neoplasm. It is regarded as a highly aggressive tumor with a worse prognosis than conventional pancreatic ductal adenocarcinoma. CASE PRESENTATION: A 54-year-old male patient presented with 3-month recurrent epigastric distress. Computed tomography of the abdomen showed a large cystic mass in the distal pancreas. On macroscopic examination, the lesion had numerous multiloculated cystic cavities. Microscopically, the tumor predominantly comprised a considerable number of evenly distributed non-neoplastic osteoclast-like giant cells and a few neoplastic pleomorphic cells. Although extensive histologic sampling was conducted, a classic ductal adenocarcinoma component was not identified. The patient received no further treatment after his surgery and has been doing well with no evidence of recurrence or metastasis for >7 years. CONCLUSIONS: Our results suggest that pure UCOGC has a significantly better prognosis and supports that pure UCOGC may represent a biologically distinct variant of pancreatic carcinoma and it should be separated from other undifferentiated pancreatic carcinomas. IJCEP