Literature DB >> 33423459

Selective and Improved Photoannealing of Microporous Annealed Particle (MAP) Scaffolds.

Blaise N Pfaff1, Lauren J Pruett1, Nicholas J Cornell1, Joseph de Rutte2, Dino Di Carlo2, Christopher B Highley1,3, Donald R Griffin1,3.   

Abstract

Microporous annealed particle (MAP) scaffolds consist of a slurry of hydrogel microspheres that undergo annealing to form a solid scaffold. MAP scaffolds have contained functional groups with dual abilities to participate in Michael-type addition (gelation) and radical polymerization (photoannealing). Functional groups with efficient Michael-type additions react with thiols and amines under physiological conditions, limiting usage for therapeutic delivery. We present a heterofunctional maleimide/methacrylamide 4-arm PEG macromer (MethMal) engineered for selective photopolymerization compatible with multiple polymer backbones. Rheology using two classes of photoinitiators demonstrates advantageous photopolymerization capabilities. Functional assays show benefits for therapeutic delivery and 3D printing without impacting cell viability.

Entities:  

Keywords:  3D printing; MAP; photopolymerization; porous hydrogel

Mesh：

Substances：

Year:  2021        PMID： 33423459      PMCID： PMC8408836          DOI： 10.1021/acsbiomaterials.0c01580

Source DB:  PubMed          Journal:  ACS Biomater Sci Eng        ISSN： 2373-9878


  16 in total

Review 1.  Photopolymerizable hydrogels for tissue engineering applications.

Authors:  Kytai Truong Nguyen; Jennifer L West
Journal:  Biomaterials       Date:  2002-11       Impact factor: 12.479

2.  Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks.

Authors:  Donald R Griffin; Westbrook M Weaver; Philip O Scumpia; Dino Di Carlo; Tatiana Segura
Journal:  Nat Mater       Date:  2015-06-01       Impact factor: 43.841

3.  Thiol-ene click hydrogels for therapeutic delivery.

Authors:  Prathamesh M Kharkar; Matthew S Rehmann; Kelsi M Skeens; Emanual Maverakis; April M Kloxin
Journal:  ACS Biomater Sci Eng       Date:  2016-01-11

4.  Injectable Microannealed Porous Scaffold for Articular Cartilage Regeneration.

Authors:  Christine Schaeffer; Blaise N Pfaff; Nicholas J Cornell; Lisa S Salopek; Sarah Shan; Jan Viyar; Wilson Omesiete; Donald R Griffin; Patrick S Cottler; Brent R DeGeorge
Journal:  Ann Plast Surg       Date:  2020-06       Impact factor: 1.539

5.  3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking.

Authors:  Liliang Ouyang; Christopher B Highley; Christopher B Rodell; Wei Sun; Jason A Burdick
Journal:  ACS Biomater Sci Eng       Date:  2016-06-09

6.  Particle Hydrogels Based on Hyaluronic Acid Building Blocks.

Authors:  Elias Sideris; Donald R Griffin; Yichen Ding; Shuoran Li; Westbrook M Weaver; Dino Di Carlo; Tzung Hsiai; Tatiana Segura
Journal:  ACS Biomater Sci Eng       Date:  2016-09-27

7.  Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery.

Authors:  Edward A Phelps; Nduka O Enemchukwu; Vincent F Fiore; Jay C Sy; Niren Murthy; Todd A Sulchek; Thomas H Barker; Andrés J García
Journal:  Adv Mater       Date:  2011-12-16       Impact factor: 30.849

8.  Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility.

Authors:  Benjamin D Fairbanks; Michael P Schwartz; Christopher N Bowman; Kristi S Anseth
Journal:  Biomaterials       Date:  2009-09-23       Impact factor: 12.479

9.  Jammed Microgel Inks for 3D Printing Applications.

Authors:  Christopher B Highley; Kwang Hoon Song; Andrew C Daly; Jason A Burdick
Journal:  Adv Sci (Weinh)       Date:  2018-10-24       Impact factor: 16.806
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  4 in total

1.  Heparin Microislands in Microporous Annealed Particle Scaffolds for Accelerated Diabetic Wound Healing.

Authors:  Lauren Pruett; Christian Jenkins; Neharika Singh; Katarina Catallo; Donald Griffin
Journal:  Adv Funct Mater       Date:  2021-06-18       Impact factor: 19.924

2.  Sticking Together: Injectable Granular Hydrogels with Increased Functionality via Dynamic Covalent Inter-Particle Crosslinking.

Authors:  Victoria G Muir; Taimoor H Qazi; Shoshana Weintraub; Bryan O Torres Maldonado; Paulo E Arratia; Jason A Burdick
Journal:  Small       Date:  2022-03-22       Impact factor: 15.153

3.  Spatially heterogeneous epidermal growth factor release from microporous annealed particle (MAP) hydrogel for improved wound closure.

Authors:  Lauren Pruett; Regan Ellis; Meghan McDermott; Colleen Roosa; Donald Griffin
Journal:  J Mater Chem B       Date:  2021-09-15       Impact factor: 7.571

Review 4.  Mechanical reinforcement of granular hydrogels.

Authors:  Alvaro Charlet; Francesca Bono; Esther Amstad
Journal:  Chem Sci       Date:  2022-02-15       Impact factor: 9.825
  4 in total

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