Li-Xue Yin1, Chun-Yan Ma2, Shan Wang1, Yong-Huai Wang2, Ping-Ping Meng2, Xiao-Fang Pan3, Jun Yang2, Yu-Hua Zhang4, Ming-Hui Liu5, Ming-Xing Li6, Jie Gao7, Qiang Wu8, Ning-Na Feng9, Yi-Yun Wu10, Jian-Xing Zhang11, Li Xue12, Feng-Ling Chang13, Li Chen14, Yi-Xue Sun15, Jian-Jun Yuan16, Shun-Shi Yang17, Hong-Yuan Xue18, Ling-Zhi Ma19, Xue-Zhong Jiang20, Jing Li21, Li-Qiang Zheng22, Wei-Dong Ren23. 1. Department of Cardiovascular Ultrasound & Noninvasive Cardiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China. 2. Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, China. 3. Health Medical Department, Dalian Municipal Central Hospital, Dalian, China. 4. Department of Ultrasound, The Third People's Hospital of Zhengzhou, Zhengzhou, China. 5. Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China. 6. Department of Ultrasound Diagnosis, The Affiliated Hospital of Southwest Medical University, Luzhou, China. 7. Department of Ultrasound, Affiliated Hospital of Yan'an University, Yan'an, China. 8. Ultrasound Department, Central Hospital of Chongqing Three Gorges, Chongqing, China. 9. Medical Technology Department, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, China. 10. Department of Ultrasound, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. 11. Ultrasonic Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China. 12. Department of Cardiac Ultrasound, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China. 13. Department of Ultrasound, Xinxiang Central Hospital, Xinxiang, China. 14. Department of Ultrasound, The First Affiliated Hospital of Nanchang University, Nanchang, China. 15. Ultrasonic Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China. 16. Ultrasonography Department, Henan Provincial People's Hospital, Zhengzhou, China. 17. Department of Medical Ultrasound, The Central Hospital of Wuhan, Wuhan, China. 18. Department of Ultrasound, Hebei General Hospital, Shijiazhuang, China. 19. Department of Ultrasound, The Fourth Affiliated Hospital of China Medical University, Shenyang, China. 20. Department of Medical Ultrasound, Geriatric Hospital of Nanjing Medical University & Jiangsu Provincial Geriatric Hospital, Nanjing, China. 21. Ultrasonography Department, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China. 22. Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, Shenyang, China. 23. Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: renwd01@163.com.
Abstract
BACKGROUND: Ultrafast ultrasound imaging has been demonstrated to be an effective method to evaluate carotid stiffness through carotid pulse-wave velocity (PWV) with high reproducibility, but a lack of reference values has precluded its widespread use in clinical practice. The aims of this study were to establish reference values of PWV for ultrafast ultrasound imaging in a prospective, multicenter, population-based cohort study and to investigate the main determinants of carotid PWV. METHODS: A total of 1,544 healthy Han Chinese volunteers (581 men [38%]; age range, 18-95 years) were enrolled from 32 collaborating laboratories in China. The participants were categorized by age, blood pressure (BP), and body mass index (BMI). Basic clinical parameters and carotid PWV at the beginning of systole (BS) and at end-systole (ES) were measured using ultrafast ultrasound imaging techniques. RESULTS: PWV at both BS and ES was significantly higher in the left carotid artery than in the right carotid artery. PWV at BS was significantly higher in men than in women; however, no significant difference was noted in PWV at ES between men and women. Multiple linear regression analyses revealed that age, BP, and BMI were independently correlated with PWV at both BS and ES. PWV at BS and ES progressively increased with increases in age, BP, and BMI. Furthermore, age- and sex-specific reference values of carotid PWV for ultrafast ultrasound imaging were established. CONCLUSIONS: Reference values of carotid PWV for ultrafast ultrasound imaging, stratified by sex and age, were determined for the first time. Age, BP, and BMI were the dominant determinants of carotid PWV for ultrafast ultrasound imaging, which should be considered in clinical practice for assessing arterial stiffness.
BACKGROUND: Ultrafast ultrasound imaging has been demonstrated to be an effective method to evaluate carotid stiffness through carotid pulse-wave velocity (PWV) with high reproducibility, but a lack of reference values has precluded its widespread use in clinical practice. The aims of this study were to establish reference values of PWV for ultrafast ultrasound imaging in a prospective, multicenter, population-based cohort study and to investigate the main determinants of carotid PWV. METHODS: A total of 1,544 healthy Han Chinese volunteers (581 men [38%]; age range, 18-95 years) were enrolled from 32 collaborating laboratories in China. The participants were categorized by age, blood pressure (BP), and body mass index (BMI). Basic clinical parameters and carotid PWV at the beginning of systole (BS) and at end-systole (ES) were measured using ultrafast ultrasound imaging techniques. RESULTS: PWV at both BS and ES was significantly higher in the left carotid artery than in the right carotid artery. PWV at BS was significantly higher in men than in women; however, no significant difference was noted in PWV at ES between men and women. Multiple linear regression analyses revealed that age, BP, and BMI were independently correlated with PWV at both BS and ES. PWV at BS and ES progressively increased with increases in age, BP, and BMI. Furthermore, age- and sex-specific reference values of carotid PWV for ultrafast ultrasound imaging were established. CONCLUSIONS: Reference values of carotid PWV for ultrafast ultrasound imaging, stratified by sex and age, were determined for the first time. Age, BP, and BMI were the dominant determinants of carotid PWV for ultrafast ultrasound imaging, which should be considered in clinical practice for assessing arterial stiffness.
Authors: Judith T Pruijssen; Joyce Wilbers; Frederick J A Meijer; Sjoert A H Pegge; Jacqueline J Loonen; Chris L de Korte; Johannes H A M Kaanders; Hendrik H G Hansen Journal: Radiat Oncol Date: 2022-07-23 Impact factor: 4.309