Fang-Yu Cheng1, Yuanmay Chang1, Shih-Jung Cheng2,3,4, Jin-Siang Shaw5, Chuo-Yu Lee2,3,6, Pei-Hao Chen7,8,9. 1. Institute of Long-Term Care, Mackay Medical College, New Taipei City, Taiwan. 2. Department of Neurology, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd, Taipei, 10449, Taiwan. 3. Department of Medicine, Mackay Medical College, New Taipei City, Taiwan. 4. Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan. 5. Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan. 6. Graduate Institute of Chemistry, Tamkang University, New Taipei City, Taiwan. 7. Department of Neurology, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd, Taipei, 10449, Taiwan. a7662888@gmail.com. 8. Department of Medicine, Mackay Medical College, New Taipei City, Taiwan. a7662888@gmail.com. 9. Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan. a7662888@gmail.com.
Abstract
BACKGROUND: Motoric cognitive risk syndrome (MCR) is defined by slow gait speed combined with subjective cognitive complaint. MCR is a predementia syndrome, similar to mild cognitive impairment (MCI). However, there is currently no study comparing the differences in cognitive performance and physical function between these two types of cognitive impairment. Thus, the aim of this study is to compare cognitive performance and physical function in individuals with MCR versus MCI. METHODS: A total of 77 participants, free of dementia, were recruited from the neurological outpatient clinic of a medical center in Taiwan. Participants were separated into 2 groups, MCR (n = 33) and MCI (n = 44) groups, based on definition criteria from previous studies. The priority was to assign a diagnosis of MCR first, followed by MCI. Hence, "pure" MCI had no overlap with MCR syndrome. Cognitive performance, including executive function, attention, working memory, episode memory, visuospatial function, and language, were measured. Physical functions such as activities in daily living, the Tinetti Assessment Scale, and the Timed Up and Go test were also measured. RESULTS: Executive function, attention, working memory, episodic memory and language were all significantly lower in the MCR group than the MCI group. Abilities related to physical function, including those measured by the Tinetti Assessment Scale and the Timed Up and Go test, were significantly lower in the MCR group than the MCI group. CONCLUSIONS: We noted that cognitive performance and physical function were lower in MCR individuals than MCI but without MCR syndrome. However, the conclusions were based on the enrollment procedure of participants prioritizes the MCR syndrome. Because of the overlap of MCR and MCI, future studies should use different enrollment strategies to further clarify the status of these two populations.
BACKGROUND:Motoric cognitive risk syndrome (MCR) is defined by slow gait speed combined with subjective cognitive complaint. MCR is a predementia syndrome, similar to mild cognitive impairment (MCI). However, there is currently no study comparing the differences in cognitive performance and physical function between these two types of cognitive impairment. Thus, the aim of this study is to compare cognitive performance and physical function in individuals with MCR versus MCI. METHODS: A total of 77 participants, free of dementia, were recruited from the neurological outpatient clinic of a medical center in Taiwan. Participants were separated into 2 groups, MCR (n = 33) and MCI (n = 44) groups, based on definition criteria from previous studies. The priority was to assign a diagnosis of MCR first, followed by MCI. Hence, "pure" MCI had no overlap with MCR syndrome. Cognitive performance, including executive function, attention, working memory, episode memory, visuospatial function, and language, were measured. Physical functions such as activities in daily living, the Tinetti Assessment Scale, and the Timed Up and Go test were also measured. RESULTS: Executive function, attention, working memory, episodic memory and language were all significantly lower in the MCR group than the MCI group. Abilities related to physical function, including those measured by the Tinetti Assessment Scale and the Timed Up and Go test, were significantly lower in the MCR group than the MCI group. CONCLUSIONS: We noted that cognitive performance and physical function were lower in MCR individuals than MCI but without MCR syndrome. However, the conclusions were based on the enrollment procedure of participants prioritizes the MCR syndrome. Because of the overlap of MCR and MCI, future studies should use different enrollment strategies to further clarify the status of these two populations.
Authors: Chiung Chih Chang; Joel H Kramer; Ker Neng Lin; Wen Neng Chang; Ya-Ling Wang; Chi-Wei Huang; Yu Ting Lin; Ching Chen; Pei Ning Wang Journal: J Int Neuropsychol Soc Date: 2009-12-11 Impact factor: 2.892
Authors: N L Watson; C Rosano; R M Boudreau; E M Simonsick; L Ferrucci; K Sutton-Tyrrell; S E Hardy; H H Atkinson; K Yaffe; S Satterfield; T B Harris; A B Newman Journal: J Gerontol A Biol Sci Med Sci Date: 2010-06-25 Impact factor: 6.053
Authors: H Villars; S Oustric; S Andrieu; J P Baeyens; R Bernabei; H Brodaty; K Brummel-Smith; C Celafu; N Chappell; J Fitten; G Frisoni; L Froelich; O Guerin; G Gold; I Holmerova; S Iliffe; A Lukas; R Melis; J E Morley; H Nies; F Nourhashemi; J Petermans; J Ribera Casado; L Rubenstein; A Salva; C Sieber; A Sinclair; R Schindler; E Stephan; R Y Wong; B Vellas Journal: J Nutr Health Aging Date: 2010-02 Impact factor: 4.075
Authors: Hal H Atkinson; Caterina Rosano; Eleanor M Simonsick; Jeff D Williamson; Cralen Davis; Walter T Ambrosius; Stephen R Rapp; Matteo Cesari; Anne B Newman; Tamara B Harris; Susan M Rubin; Kristine Yaffe; Suzanne Satterfield; Stephen B Kritchevsky Journal: J Gerontol A Biol Sci Med Sci Date: 2007-08 Impact factor: 6.053