Jon Gitz Holler1, Robert Eriksson2,3, Tomas Østergaard Jensen2, Maarten van Wijhe2,4, Thea Kølsen Fischer2,5, Ole Schmeltz Søgaard6, Simone Bastrup Israelsen7, Rajesh Mohey8, Thilde Fabricius9, Frederik Jøhnk10, Lothar Wiese11, Stine Johnsen12, Christian Søborg13, Henrik Nielsen14, Ole Kirk15, Birgitte Lindegaard Madsen2,16, Zitta Barrella Harboe2. 1. Department of Pulmonary and Infectious Diseases, University Hospital of Copenhagen, North Zealand Hospital, Hillerød, Denmark. Jon.Gitz.Holler@regionh.dk. 2. Department of Pulmonary and Infectious Diseases, University Hospital of Copenhagen, North Zealand Hospital, Hillerød, Denmark. 3. Department of Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark. 4. Department of Science and Environment, Roskilde University, Roskilde, Denmark. 5. University of Southern Denmark, Odense, Denmark. 6. Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. 7. Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark. 8. Department of Internal Medicine, Aarhus University Hospital, Herning, Denmark. 9. Department of Infectious Diseases, University Hospital of Southern Denmark, Odense, Denmark. 10. Department of Infectious Diseases, Lillebaelt Hospital, Vejle, Denmark. 11. Department of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark. 12. Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital, Bispebjerg, Denmark. 13. Department of Infectious Diseases, Copenhagen University Hospital, and Gentofte, Herlev, Denmark. 14. Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark. 15. Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark. 16. Centre for Physical Activity, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Abstract
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. METHODS: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. RESULTS: Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53-80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia and thrombocytopenia within ±24-h of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were independently associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. CONCLUSIONS: Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were independent factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher in males after surviving the first week.
BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. METHODS: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. RESULTS: Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53-80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia and thrombocytopenia within ±24-h of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were independently associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. CONCLUSIONS: Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were independent factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher in males after surviving the first week.
Authors: Ricardo S Santos; Danilo S Barros; Thiago M P Moraes; Cintya Y Hayashi; Renata B Ralio; Fernanda F Minenelli; Kees van Zon; João P S Ripardo Journal: IJID Reg Date: 2022-04-14
Authors: Stine Johnsen; Stefan M Sattler; Kamilla Woznica Miskowiak; Keerthana Kunalan; Alan Victor; Lars Pedersen; Helle Frost Andreassen; Barbara Jolanta Jørgensen; Hanne Heebøll; Michael Brun Andersen; Lisbeth Marner; Carsten Hædersdal; Henrik Hansen; Sisse Bolm Ditlev; Celeste Porsbjerg; Thérèse S Lapperre Journal: ERJ Open Res Date: 2021-08-02
Authors: Tayfun Birtay; Suzan Bahadir; Ebru Kabacaoglu; Ozgur Yetiz; Mehmet Fatih Demirci; Gultekin Genctoy Journal: Ann Saudi Med Date: 2021-12-02 Impact factor: 1.707