Wojciech Durlak1, Małgorzata Klimek1, Michał Wroński1, Angelica Trybulska2, Przemko Kwinta3. 1. Jagiellonian University Medical College, Department of Pediatrics, Krakow, Poland. 2. Jagiellonian University Medical College, Student Scientific Association, Krakow, Poland. 3. Jagiellonian University Medical College, Department of Pediatrics, Krakow, Poland. Electronic address: przemko.kwinta@uj.edu.pl.
Abstract
PURPOSE: Preterm birth is associated with adverse pulmonary outcomes. We aimed to evaluate respiratory morbidities and lung function of very low birth weight (VLBW) Polish children followed up at the age of 7 years old, and to compare with electrical impedance segmentography (EIS) results recorded at 4 years of age. MATERIALS AND METHODS: VLBW children were compared with term controls using impulse oscillometry and spirometry. Perinatal data and current respiratory morbidities were analyzed and pulmonary function test results were compared with previous EIS results. RESULTS: We included 40 VLBW children and 30 controls in the analysis. Elevated total airway resistance and forced expiratory volume in the first second below the lower limit of normal were more prevalent in VLBW children compared with term controls (15 vs 0%; 18 vs 0%). A positive bronchodilator response was more common in VLBW children (R5 Hz: 46 vs 13.3%; R5-20 Hz: 65 vs 36.7%). Children with bronchopulmonary dysplasia (BPD) had higher total airway resistance (R5 Hz/R5 Hz pred: 1.35 vs 0.95; p < 0.001), large airway resistance (R20 Hz/R20 Hz pred: 0.89 vs 0.66; p = 0.001), small airway resistance (R5-20 Hz: 0.57 vs 0.34 kPa L-1 s-1; p = 0.009), than controls. Strong correlation between BDR in EIS and R5 Hz/R5 Hz pred was observed in children with BPD (r = 0.7). CONCLUSION: VLBW school-aged children with BPD presented with substantial respiratory morbidity and persistent reduction of lung function, affecting small and large airways and lung parenchyma. EIS may be an alternative tool for lung function assessment in children with BPD.
PURPOSE: Preterm birth is associated with adverse pulmonary outcomes. We aimed to evaluate respiratory morbidities and lung function of very low birth weight (VLBW) Polish children followed up at the age of 7 years old, and to compare with electrical impedance segmentography (EIS) results recorded at 4 years of age. MATERIALS AND METHODS: VLBW children were compared with term controls using impulse oscillometry and spirometry. Perinatal data and current respiratory morbidities were analyzed and pulmonary function test results were compared with previous EIS results. RESULTS: We included 40 VLBW children and 30 controls in the analysis. Elevated total airway resistance and forced expiratory volume in the first second below the lower limit of normal were more prevalent in VLBW children compared with term controls (15 vs 0%; 18 vs 0%). A positive bronchodilator response was more common in VLBW children (R5 Hz: 46 vs 13.3%; R5-20 Hz: 65 vs 36.7%). Children with bronchopulmonary dysplasia (BPD) had higher total airway resistance (R5 Hz/R5 Hz pred: 1.35 vs 0.95; p < 0.001), large airway resistance (R20 Hz/R20 Hz pred: 0.89 vs 0.66; p = 0.001), small airway resistance (R5-20 Hz: 0.57 vs 0.34 kPa L-1 s-1; p = 0.009), than controls. Strong correlation between BDR in EIS and R5 Hz/R5 Hz pred was observed in children with BPD (r = 0.7). CONCLUSION: VLBW school-aged children with BPD presented with substantial respiratory morbidity and persistent reduction of lung function, affecting small and large airways and lung parenchyma. EIS may be an alternative tool for lung function assessment in children with BPD.
Authors: Seyram Kaali; Darby W Jack; Rebecca K D Prah; Steven N Chillrud; Mohammed N Mujtaba; Patrick L Kinney; Theresa Tawiah; Qiang Yang; Felix B Oppong; Carlos F Gould; Musah Osei; Blair J Wylie; Oscar Agyei; Matthew S Perzanowski; Kwaku Poku Asante; Alison G Lee Journal: Pediatr Pulmonol Date: 2022-06-13