Wade Muncey1,2, Nicholas Sellke3,4, Tyler Kim3, Kirtishri Mishra3,4, Nannan Thirumavalavan3,4, Aram Loeb3,4. 1. Case Western Reserve University School of Medicine, Cleveland, OH, USA. Wade.Muncey@uhhospitals.org. 2. University Hospitals Cleveland Medical Center, Urology Institute, Mailstop LKS 5046, 11100 Euclid Ave, Cleveland, OH, 44106, USA. Wade.Muncey@uhhospitals.org. 3. Case Western Reserve University School of Medicine, Cleveland, OH, USA. 4. University Hospitals Cleveland Medical Center, Urology Institute, Mailstop LKS 5046, 11100 Euclid Ave, Cleveland, OH, 44106, USA.
Abstract
PURPOSE OF REVIEW: To highlight and review encouraging preliminary studies behind several alternative products and interventions for erectile dysfunction (ED). RECENT FINDINGS: Alternative treatments for ED are becoming more prevalent with increased consumer interest. "Natural" products are sold online, and numerous clinics offer various off-label and investigational interventions. These alternative treatments have demonstrated varying degrees of efficacy in randomized trials and meta-analyses, but none of these interventions has robust enough evidence to be considered first-line therapy. These treatments may find a role in combination with guideline treatments or may be used in novel penile rehabilitation research protocols. With growing interest in alternative treatment for men's health, an awareness of the literature is imperative for patient counsel. Alternative treatments, like L-arginine, have a growing body of evidence for efficacy in combination with PDE5i, and low-intensity shock wave therapy and stem cell therapy continue to demonstrate encouraging outcomes in ED trials.
PURPOSE OF REVIEW: To highlight and review encouraging preliminary studies behind several alternative products and interventions for erectile dysfunction (ED). RECENT FINDINGS: Alternative treatments for ED are becoming more prevalent with increased consumer interest. "Natural" products are sold online, and numerous clinics offer various off-label and investigational interventions. These alternative treatments have demonstrated varying degrees of efficacy in randomized trials and meta-analyses, but none of these interventions has robust enough evidence to be considered first-line therapy. These treatments may find a role in combination with guideline treatments or may be used in novel penile rehabilitation research protocols. With growing interest in alternative treatment for men's health, an awareness of the literature is imperative for patient counsel. Alternative treatments, like L-arginine, have a growing body of evidence for efficacy in combination with PDE5i, and low-intensity shock wave therapy and stem cell therapy continue to demonstrate encouraging outcomes in ED trials.
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